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Literature DB >> 25216676

tRNAs: new tricks from old dogs.

Abstract

tRNA biology has lately seen a revival with the discovery of tRNA cleavage products as mediators of stress responses. In this issue of The EMBO Journal, Blanco et al now report that tRNA methylation, by protecting from cleavage, is relevant for normal brain development. The versatility of tRNA is further emphasized by a recent study in Cell that uncovered differential expression of tRNAs as a means to accustom codon usage bias to the needs in proliferating versus differentiating cells.

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Year: 2014 PMID： 25216676 PMCID： PMC4195766 DOI： 10.15252/embj.201489634

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

13 in total

1. An evolutionarily conserved mechanism for controlling the efficiency of protein translation.

Authors: Tamir Tuller; Asaf Carmi; Kalin Vestsigian; Sivan Navon; Yuval Dorfan; John Zaborske; Tao Pan; Orna Dahan; Itay Furman; Yitzhak Pilpel
Journal: Cell Date: 2010-04-16 Impact factor: 41.582

2. Stressing out over tRNA cleavage.

Authors: Debrah M Thompson; Roy Parker
Journal: Cell Date: 2009-07-23 Impact factor: 41.582

3. RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.

Authors: Matthias Schaefer; Tim Pollex; Katharina Hanna; Francesca Tuorto; Madeleine Meusburger; Mark Helm; Frank Lyko
Journal: Genes Dev Date: 2010-08-01 Impact factor: 11.361

4. A dual program for translation regulation in cellular proliferation and differentiation.

Authors: Hila Gingold; Disa Tehler; Nanna R Christoffersen; Morten M Nielsen; Fazila Asmar; Susanne M Kooistra; Nicolaj S Christophersen; Lise Lotte Christensen; Michael Borre; Karina D Sørensen; Lars D Andersen; Claus L Andersen; Esther Hulleman; Tom Wurdinger; Elisabeth Ralfkiær; Kristian Helin; Kirsten Grønbæk; Torben Ørntoft; Sebastian M Waszak; Orna Dahan; Jakob Skou Pedersen; Anders H Lund; Yitzhak Pilpel
Journal: Cell Date: 2014-09-11 Impact factor: 41.582

5. Angiogenin-induced tRNA fragments inhibit translation initiation.

Authors: Pavel Ivanov; Mohamed M Emara; Judit Villen; Steven P Gygi; Paul Anderson
Journal: Mol Cell Date: 2011-08-19 Impact factor: 17.970

Review 6. Early days of tRNA research: discovery, function, purification and sequence analysis.

Authors: Uttam L RajBhandary; Caroline Köhrer
Journal: J Biosci Date: 2006-10 Impact factor: 2.795

7. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels.

Authors: Milana Frenkel-Morgenstern; Tamar Danon; Thomas Christian; Takao Igarashi; Lydia Cohen; Ya-Ming Hou; Lars Juhl Jensen
Journal: Mol Syst Biol Date: 2012-02-28 Impact factor: 11.429

8. Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.

Authors: Sandra Blanco; Sabine Dietmann; Joana V Flores; Shobbir Hussain; Claudia Kutter; Peter Humphreys; Margus Lukk; Patrick Lombard; Lucas Treps; Martyna Popis; Stefanie Kellner; Sabine M Hölter; Lillian Garrett; Wolfgang Wurst; Lore Becker; Thomas Klopstock; Helmut Fuchs; Valerie Gailus-Durner; Martin Hrabĕ de Angelis; Ragnhildur T Káradóttir; Mark Helm; Jernej Ule; Joseph G Gleeson; Duncan T Odom; Michaela Frye
Journal: EMBO J Date: 2014-07-25 Impact factor: 11.598

tRNAs: new tricks from old dogs.

1. An evolutionarily conserved mechanism for controlling the efficiency of protein translation.

2. Stressing out over tRNA cleavage.

3. RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.

4. A dual program for translation regulation in cellular proliferation and differentiation.

5. Angiogenin-induced tRNA fragments inhibit translation initiation.

Review 6. Early days of tRNA research: discovery, function, purification and sequence analysis.

7. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels.

8. Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.

9. tRNA over-expression in breast cancer and functional consequences.

10. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

1. Coevolution mechanisms that adapt viruses to genetic code variations implemented in their hosts.

Review 2. tRNA-derived small RNAs: New players in genome protection against retrotransposons.

3. tRNA-derived small RNAs target transposable element transcripts.

4. Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes.