Literature DB >> 2521647

Decreased plasma tryptophan levels in major depression.

P J Cowen1, M Parry-Billings, E A Newsholme.   

Abstract

Total plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation between basal tryptophan concentrations in the depressed subjects and the subsequent neuroendocrine response to intravenous tryptophan.

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Year:  1989        PMID： 2521647     DOI： 10.1016/0165-0327(89)90051-7

Source DB:  PubMed          Journal:  J Affect Disord        ISSN： 0165-0327            Impact factor:   4.839


  35 in total

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