| Literature DB >> 25216367 |
Subhi A Al-Jibori1, Ghassan H Al-Jibori2, Lamaan J Al-Hayaly3, Christoph Wagner4, Harry Schmidt4, Suna Timur5, F Baris Barlas5, Elif Subasi6, Shishir Ghosh7, Graeme Hogarth8.
Abstract
The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2] x H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.Entities:
Keywords: Ammine; Anti-cancer; Cisplatin; Saccharinate; Thiosaccharinate; X-ray structure
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Year: 2014 PMID： 25216367 DOI： 10.1016/j.jinorgbio.2014.07.017
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155