Literature DB >> 2521599

Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure.

N Cohen1, D Modai, A Golik, J Weissgarten, S Peller, A Katz, Z Averbukh, U Shaked.   

Abstract

E-rosette-forming cells (E-RFC), mitogen-induced blast transformation, OKT4+, OKT8+ cells, and their ratio were found to be normal in 10 subjects chronically exposed to lead with blood levels of 40-51 micrograms%. However, concanavalin A (Con A)-induced suppressor cell activity (SCA) in these subjects was significantly greater than in normal matched controls. The clinical relevance of this observation is not clear, but it may have some bearing on the various immunologic defects described in lead exposure.

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Year:  1989        PMID: 2521599     DOI: 10.1016/s0013-9351(89)80079-9

Source DB:  PubMed          Journal:  Environ Res        ISSN: 0013-9351            Impact factor:   6.498


  2 in total

1.  Metals in lung tissue from autopsy cases in Mexico City residents: comparison of cases from the 1950s and the 1980s.

Authors:  T I Fortoul; L S Osorio; A T Tovar; D Salazar; M E Castilla; G Olaiz-Fernández
Journal:  Environ Health Perspect       Date:  1996-06       Impact factor: 9.031

Review 2.  Immunotoxicity of heavy metals in relation to Great Lakes.

Authors:  J Bernier; P Brousseau; K Krzystyniak; H Tryphonas; M Fournier
Journal:  Environ Health Perspect       Date:  1995-12       Impact factor: 9.031

  2 in total

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