Literature DB >> 25214153

Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis.

Shinobu Kitazume1, Rie Imamaki2, Kazuko Ogawa2, Naoyuki Taniguchi1.   

Abstract

The vascular endothelial glycocalyx contains several anionic sugars, one of which is a sialic acid attached to both N- and O-glycans. Platelet endothelial cell adhesion molecule (PECAM), a member of the Ig superfamily that plays multiple roles in cell adhesion, mechanical stress sensing, antiapoptosis and angiogenesis, has recently been shown to recognize α2,6-sialic acid. In endothelial cells that lack α2,6-sialic acid because of sialyltransferase ST6Gal I deficiency, impairment of the homophilic PECAM interaction and PECAM-dependent cell survival signaling is observed. In this review, we will introduce part of the biological role of PECAM, and discuss how the lectin activity of PECAM is related to angiogenesis.
© The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  PECAM; ST6Gal I; angiogenesis; lectin; sialic acid

Mesh：

Substances：

Year:  2014        PMID： 25214153     DOI： 10.1093/glycob/cwu094

Source DB:  PubMed          Journal:  Glycobiology        ISSN： 0959-6658            Impact factor:   4.313


  9 in total

1.  Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells.

Authors:  Florent Colomb; Weikun Wang; Deborah Simpson; Mudaser Zafar; Robert Beynon; Jonathan M Rhodes; Lu-Gang Yu
Journal:  J Biol Chem       Date:  2017-03-31       Impact factor: 5.157

2.  VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis.

Authors:  Chandran S Abhinand; Rajesh Raju; Sasikumar J Soumya; Prabha S Arya; Perumana R Sudhakaran
Journal:  J Cell Commun Signal       Date:  2016-09-12       Impact factor: 5.782

3.  Glycosylation controls cooperative PECAM-VEGFR2-β3 integrin functions at the endothelial surface for tumor angiogenesis.

Authors:  Rie Imamaki; Kazuko Ogawa; Yasuhiko Kizuka; Yusuke Komi; Soichi Kojima; Norihiro Kotani; Koichi Honke; Takashi Honda; Naoyuki Taniguchi; Shinobu Kitazume
Journal:  Oncogene       Date:  2018-05-02       Impact factor: 9.867

Review 4.  Biological roles of glycans.

Authors:  Ajit Varki
Journal:  Glycobiology       Date:  2016-08-24       Impact factor: 4.313

5.  PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus.

Authors:  Matej Završnik; Stojan Kariž; Jana Makuc; Maja Šeruga; Ines Cilenšek; Daniel Petrovič
Journal:  Anal Cell Pathol (Amst)       Date:  2016-12-28       Impact factor: 2.916

Review 6.  Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis.

Authors:  Kevin Brown Chandler; Catherine E Costello; Nader Rahimi
Journal:  Cells       Date:  2019-06-05       Impact factor: 6.600

7.  IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis.

Authors:  Jau-Ling Suen; Yu Chang; Yu-Shiang Shiu; Chia-Yi Hsu; Pooja Sharma; Chien-Chih Chiu; Yi-Ju Chen; Tzyh-Chyuan Hour; Eing-Mei Tsai
Journal:  J Pathol       Date:  2019-10-06       Impact factor: 7.996

8.  Plump endothelial cells integrated into pre-existing venules contribute to the formation of 'mother' and 'daughter' vessels in pyogenic granuloma: possible role of galectin-1, -3 and -8.

Authors:  Enrique Arciniegas; Luz Marina Carrillo; Héctor Rojas; Jacinto Pineda; Richard Ramírez; Oscar Reyes; Marina Chopite; Albani Rocheta
Journal:  Scars Burn Heal       Date:  2021-01-22

9.  Congenital thrombocytopenia associated with GNE mutations in twin sisters: a case report and literature review.

Authors:  Xin Li; Ying Li; Min Lei; Jing Tian; Zuocheng Yang; Shoujin Kuang; Yanjuan Tan; Tao Bo
Journal:  BMC Med Genet       Date:  2020-11-16       Impact factor: 2.103
  9 in total

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