Literature DB >> 25213168

Stress-induced mutation rates show a sigmoidal and saturable increase due to the RpoS sigma factor in Escherichia coli.

Ram Maharjan1, Thomas Ferenci2.   

Abstract

Stress-induced mutagenesis was investigated in the absence of selection for growth fitness by using synthetic biology to control perceived environmental stress in Escherichia coli. We find that controlled intracellular RpoS dosage is central to a sigmoidal, saturable three- to fourfold increase in mutation rates and associated changes in DNA repair proteins.
Copyright © 2014 by the Genetics Society of America.

Entities:  

Keywords:  DNA repair; Escherichia coli; dinB; mutS; mutation rates; stress

Mesh：

Substances：

Year:  2014        PMID： 25213168      PMCID： PMC4224162          DOI： 10.1534/genetics.114.170258

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  29 in total

1.  Fidelity and infidelity.

Authors:  M Radman
Journal:  Nature       Date:  2001-09-13       Impact factor: 49.962

2.  Polymerases leave fingerprints: analysis of the mutational spectrum in Escherichia coli rpoB to assess the role of polymerase IV in spontaneous mutation.

Authors:  Erika Wolff; Mandy Kim; Kaibin Hu; Hanjing Yang; Jeffrey H Miller
Journal:  J Bacteriol       Date:  2004-05       Impact factor: 3.490

3.  RpoS, the stress response sigma factor, plays a dual role in the regulation of Escherichia coli's error-prone DNA polymerase IV.

Authors:  Kimberly A M Storvik; Patricia L Foster
Journal:  J Bacteriol       Date:  2010-05-14       Impact factor: 3.490

Review 4.  Stress-induced mutagenesis in bacteria.

Authors:  Patricia L Foster
Journal:  Crit Rev Biochem Mol Biol       Date:  2007 Sep-Oct       Impact factor: 8.250

5.  Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.

Authors:  Heewook Lee; Ellen Popodi; Haixu Tang; Patricia L Foster
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-18       Impact factor: 11.205

Review 6.  Functional modulation of Escherichia coli RNA polymerase.

Authors:  A Ishihama
Journal:  Annu Rev Microbiol       Date:  2000       Impact factor: 15.500

7.  Identity and function of a large gene network underlying mutagenic repair of DNA breaks.

Authors:  Abu Amar M Al Mamun; Mary-Jane Lombardo; Chandan Shee; Andreas M Lisewski; Caleb Gonzalez; Dongxu Lin; Ralf B Nehring; Claude Saint-Ruf; Janet L Gibson; Ryan L Frisch; Olivier Lichtarge; P J Hastings; Susan M Rosenberg
Journal:  Science       Date:  2012-12-07       Impact factor: 47.728

8.  Strain variation in ppGpp concentration and RpoS levels in laboratory strains of Escherichia coli K-12.

Authors:  Beny Spira; Xuye Hu; Thomas Ferenci
Journal:  Microbiology (Reading)       Date:  2008-09       Impact factor: 2.777

9.  Contrasting mutation rates from specific-locus and long-term mutation-accumulation procedures.

Authors:  John W Drake
Journal:  G3 (Bethesda)       Date:  2012-04-01       Impact factor: 3.154

10.  Elevated mutagenesis does not explain the increased frequency of antibiotic resistant mutants in starved aging colonies.

Authors:  Sophia Katz; Ruth Hershberg
Journal:  PLoS Genet       Date:  2013-11-14       Impact factor: 5.917
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  2 in total

1.  A shifting mutational landscape in 6 nutritional states: Stress-induced mutagenesis as a series of distinct stress input-mutation output relationships.

Authors:  Ram P Maharjan; Thomas Ferenci
Journal:  PLoS Biol       Date:  2017-06-08       Impact factor: 8.029

Review 2.  Isolating Escherichia coli strains for recombinant protein production.

Authors:  Susan Schlegel; Pierre Genevaux; Jan-Willem de Gier
Journal:  Cell Mol Life Sci       Date:  2016-10-11       Impact factor: 9.261
  2 in total

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