Literature DB >> 25213154

Understanding, treating and avoiding hematological disease: better medicine through mathematics?

David C Dale1, Michael C Mackey.   

Abstract

This paper traces the experimental, clinical and mathematical modeling efforts to understand a periodic hematological disease-cyclical neutropenia. It is primarily a highly personal account by two scientists from quite different backgrounds of their interactions over almost 40 years and their attempts to understand this intriguing disease. It's also a story of their efforts to offer effective treatments for the patients who suffer from cyclic neutropenia and other conditions causing neutropenia and infections.

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Year:  2014        PMID: 25213154      PMCID: PMC4362913          DOI: 10.1007/s11538-014-9995-x

Source DB:  PubMed          Journal:  Bull Math Biol        ISSN: 0092-8240            Impact factor:   1.758


  72 in total

1.  Oscillations in cyclical neutropenia: new evidence based on mathematical modeling.

Authors:  Samuel Bernard; Jacques Bélair; Michael C Mackey
Journal:  J Theor Biol       Date:  2003-08-07       Impact factor: 2.691

Review 2.  Cyclical neutropenia and other periodic hematological disorders: a review of mechanisms and mathematical models.

Authors:  C Haurie; D C Dale; M C Mackey
Journal:  Blood       Date:  1998-10-15       Impact factor: 22.113

3.  An analogue model of granulopoiesis for the analysis of isotopic and other data obtained in the non-steady state.

Authors:  J Reeve
Journal:  Br J Haematol       Date:  1973-07       Impact factor: 6.998

4.  Cyclic neutropenia: amplification of granulocyte oscillations by lithium and long-term suppression of cycling by plasmapheresis.

Authors:  G K von Schulthess; J Fehr; C Dahinden
Journal:  Blood       Date:  1983-08       Impact factor: 22.113

5.  The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis.

Authors:  S Schmitz; H Franke; H E Wichmann; V Diehl
Journal:  Br J Haematol       Date:  1995-05       Impact factor: 6.998

6.  The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy.

Authors:  Philip S Rosenberg; Blanche P Alter; Audrey A Bolyard; Mary Ann Bonilla; Laurence A Boxer; Bonnie Cham; Carol Fier; Melvin Freedman; George Kannourakis; Sally Kinsey; Beate Schwinzer; Connie Zeidler; Karl Welte; David C Dale
Journal:  Blood       Date:  2006-02-23       Impact factor: 22.113

7.  A novel homozygous mutation in G6PC3 presenting as cyclic neutropenia and severe congenital neutropenia in the same family.

Authors:  Abdullah A Alangari; Abdulrahman Alsultan; Mohamed Elfaki Osman; Shamsa Anazi; Fowzan S Alkuraya
Journal:  J Clin Immunol       Date:  2013-10-09       Impact factor: 8.317

8.  Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response.

Authors:  Inga Köllner; Beate Sodeik; Sabine Schreek; Holger Heyn; Nils von Neuhoff; Manuela Germeshausen; Cornelia Zeidler; Martin Krüger; Brigitte Schlegelberger; Karl Welte; Carmela Beger
Journal:  Blood       Date:  2006-03-21       Impact factor: 22.113

Review 9.  Severe congenital neutropenia and the unfolded protein response.

Authors:  Jun Xia; Daniel C Link
Journal:  Curr Opin Hematol       Date:  2008-01       Impact factor: 3.284

10.  Cyclical neutropenia and the peripheral control of white blood cell production.

Authors:  T Hearn; C Haurie; M C Mackey
Journal:  J Theor Biol       Date:  1998-05-21       Impact factor: 2.691

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  5 in total

Review 1.  Severe congenital neutropenias.

Authors:  Julia Skokowa; David C Dale; Ivo P Touw; Cornelia Zeidler; Karl Welte
Journal:  Nat Rev Dis Primers       Date:  2017-06-08       Impact factor: 52.329

2.  Response of an oscillatory differential delay equation to a single stimulus.

Authors:  Michael C Mackey; Marta Tyran-Kamińska; Hans-Otto Walther
Journal:  J Math Biol       Date:  2016-09-09       Impact factor: 2.259

3.  Transit and lifespan in neutrophil production: implications for drug intervention.

Authors:  Daniel Câmara De Souza; Morgan Craig; Tyler Cassidy; Jun Li; Fahima Nekka; Jacques Bélair; Antony R Humphries
Journal:  J Pharmacokinet Pharmacodyn       Date:  2017-12-13       Impact factor: 2.745

4.  Pharmacokinetic-pharmacodynamic modelling of neutrophil response to G-CSF in healthy subjects and patients with chemotherapy-induced neutropenia.

Authors:  Murad Melhem; Isabelle Delor; Juan Jose Pérez-Ruixo; John Harrold; Andrew Chow; Liviawati Wu; Philippe Jacqmin
Journal:  Br J Clin Pharmacol       Date:  2018-02-20       Impact factor: 4.335

Review 5.  Towards Quantitative Systems Pharmacology Models of Chemotherapy-Induced Neutropenia.

Authors:  M Craig
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2017-04-18
  5 in total

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