PURPOSE: Adaptive optics scanning laser ophthalmoscopy (AO-SLO) is a noninvasive technique that allows for the direct monitoring of erythrocyte aggregates in retinal capillaries. We analyzed the retinal hemorheologic characteristics in normal subjects, diabetic patients without diabetic retinopathy (NDR), and diabetic patients with nonproliferative diabetic retinopathy (NPDR), using spatiotemporal (ST) blood flow images to visualize blood corpuscle trajectory. METHODS: AO-SLO images of the parafoveal capillary network were acquired for three groups: 20 healthy volunteers, 17 diabetic patients with NDR (8 type 1 and 9 type 2 patients), and 10 diabetic patients with NPDR (4 type 1 and 6 type 2). The erythrocyte aggregate velocity assigned to a relative cardiac cycle and the elongation rate of the erythrocyte aggregate were calculated. RESULTS: Careful observation revealed that flow velocity fluctuations were found with higher frequency in diabetic patients than in normal subjects. The total average velocities were 1.26 ± 0.22 mm/s in the normal group, 1.31 ± 0.21 mm/s in the NDR group, and 1.63 ± 0.35 mm/s in the NPDR group. The average velocities of the NPDR group were higher than those in the normal (P = 0.001) and NDR (P = 0.009) groups. The average elongation rates of the 3 groups were 0.67 ± 0.20, 0.39 ± 0.19, and 0.33 ± 0.11, respectively. Elongation rate differed significantly between the normal and NDR (P = 0.003) groups as well as the normal and NPDR (P = 0.001) groups. CONCLUSIONS: AO-SLO can be used to detect retinal hemorheologic changes in the early stages of diabetic retinopathy. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: Adaptive optics scanning laser ophthalmoscopy (AO-SLO) is a noninvasive technique that allows for the direct monitoring of erythrocyte aggregates in retinal capillaries. We analyzed the retinal hemorheologic characteristics in normal subjects, diabeticpatients without diabetic retinopathy (NDR), and diabeticpatients with nonproliferative diabetic retinopathy (NPDR), using spatiotemporal (ST) blood flow images to visualize blood corpuscle trajectory. METHODS: AO-SLO images of the parafoveal capillary network were acquired for three groups: 20 healthy volunteers, 17 diabeticpatients with NDR (8 type 1 and 9 type 2 patients), and 10 diabeticpatients with NPDR (4 type 1 and 6 type 2). The erythrocyte aggregate velocity assigned to a relative cardiac cycle and the elongation rate of the erythrocyte aggregate were calculated. RESULTS: Careful observation revealed that flow velocity fluctuations were found with higher frequency in diabeticpatients than in normal subjects. The total average velocities were 1.26 ± 0.22 mm/s in the normal group, 1.31 ± 0.21 mm/s in the NDR group, and 1.63 ± 0.35 mm/s in the NPDR group. The average velocities of the NPDR group were higher than those in the normal (P = 0.001) and NDR (P = 0.009) groups. The average elongation rates of the 3 groups were 0.67 ± 0.20, 0.39 ± 0.19, and 0.33 ± 0.11, respectively. Elongation rate differed significantly between the normal and NDR (P = 0.003) groups as well as the normal and NPDR (P = 0.001) groups. CONCLUSIONS: AO-SLO can be used to detect retinal hemorheologic changes in the early stages of diabetic retinopathy. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Authors: Boyu Gu; Xiaolin Wang; Michael D Twa; Johnny Tam; Christopher A Girkin; Yuhua Zhang Journal: Biomed Opt Express Date: 2018-07-12 Impact factor: 3.732
Authors: Yang Lu; Miguel O Bernabeu; Jan Lammer; Charles C Cai; Martin L Jones; Claudio A Franco; Lloyd Paul Aiello; Jennifer K Sun Journal: Biomed Opt Express Date: 2016-11-04 Impact factor: 3.732
Authors: Toco Y P Chui; Shelley Mo; Brian Krawitz; Nikhil R Menon; Nadim Choudhury; Alexander Gan; Moataz Razeen; Nishit Shah; Alexander Pinhas; Richard B Rosen Journal: Int J Retina Vitreous Date: 2016-05-01