Literature DB >> 25212381

The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma.

Silvia Gramolelli1, Thomas F Schulz.   

Abstract

Kaposi sarcoma (KS) is an unusual vascular tumour caused by an oncogenic-herpesvirus, Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV 8). KS lesions are characterized by an abundant inflammatory infiltrate, the presence of KSHV-infected endothelial cells that show signs of aberrant differentiation, as well as faulty angiogenesis/ vascularization. Here we discuss the molecular mechanisms that lead to the development of these histological features of KS, with an emphasis on the viral proteins that are responsible for their development.
Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Entities:  

Keywords:  KSHV; Kaposi sarcoma; aberrant angiogenesis; atypical differentiation; inflammation; invasiveness; oncogenesis

Mesh：

Year:  2015        PMID： 25212381     DOI： 10.1002/path.4441

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  43 in total

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7.  The Viral Bcl-2 Homologs of Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Rhadinovirus Share an Essential Role for Viral Replication.

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8.  KSHV Down-regulates Tropoelastin in Both an in-vitro and in-vivo Kaposi's Sarcoma Model.

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Review 9.  Lung Malignancies in HIV Infection.

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