Literature DB >> 25212312

Protective effect of Cordyceps militaris against high glucose-induced oxidative stress in human umbilical vein endothelial cells.

Heuy-Ling Chu1, Jui-Chuan Chien2, Pin-Der Duh3.   

Abstract

The protective effect of Cordyceps militaris against high glucose-induced oxidative stress in human umbilical vein endothelial cells (HUVECs), as compared with Cordyceps sinensis, was examined. The cytotoxicity of HUVECs induced by 40mM glucose was ameliorated by water extracts of C. militaris (CME) and water extracts of C. sinensis (CSE). CME and CSE inhibited the increase in ROS and NO in HUVECs induced by 40mM high glucose. Moreover, CME increased the Bcl-2/Bax ratio, modulated the mitochondrial membrane potential and reduced the caspase-3 activity in high glucose-induced HUVECs. In addition, cordycepin, a component of CME and CSE, displayed protective effects against oxidative stress, which was partly responsible for the cytoprotective effects of CME and CSE against high glucose-induced oxidative stress in HUVECs. Overall, the obtained results show C. militaris helps preventing diabetic endothelial dysfunction and related complications.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Apoptosis; Cordyceps militaris; HUVECs; High glucose; Oxidative stress

Year:  2011        PMID： 25212312     DOI： 10.1016/j.foodchem.2011.05.037

Source DB:  PubMed          Journal:  Food Chem        ISSN： 0308-8146            Impact factor:   7.514


  7 in total

1.  Rhf1 gene is involved in the fruiting body production of Cordyceps militaris fungus.

Authors:  Keqing Jiang; Richou Han
Journal:  J Ind Microbiol Biotechnol       Date:  2015-06-06       Impact factor: 3.346

2.  Protective role of morin, a flavonoid, against high glucose induced oxidative stress mediated apoptosis in primary rat hepatocytes.

Authors:  Radhika Kapoor; Poonam Kakkar
Journal:  PLoS One       Date:  2012-08-10       Impact factor: 3.240

3.  Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin.

Authors:  Hardeep S Tuli; Sardul S Sandhu; A K Sharma
Journal:  3 Biotech       Date:  2013-02-19       Impact factor: 2.406

Review 4.  Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin.

Authors:  Chun-Ting Lee; Keng-Shiang Huang; Jei-Fu Shaw; Jung-Ren Chen; Wen-Shuo Kuo; Gangxu Shen; Alexandru Mihai Grumezescu; Alina Maria Holban; Yi-Ting Wang; Jun-Sheng Wang; Yi-Ping Hsiang; Yu-Mei Lin; Hsiao-Han Hsu; Chih-Hui Yang
Journal:  Front Pharmacol       Date:  2020-11-30       Impact factor: 5.810

5.  Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats.

Authors:  Yuan Dong; Tianjiao Jing; Qingfan Meng; Chungang Liu; Shuang Hu; Yihang Ma; Yan Liu; Jiahui Lu; Yingkun Cheng; Di Wang; Lirong Teng
Journal:  Biomed Res Int       Date:  2014-03-11       Impact factor: 3.411

6.  Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties.

Authors:  Himal Luitel; Tatyana Novoyatleva; Akylbek Sydykov; Aleksandar Petrovic; Argen Mamazhakypov; Bhuminand Devkota; Malgorzata Wygrecka; Hossein Ardeschir Ghofrani; Sergey Avdeev; Ralph Theo Schermuly; Djuro Kosanovic
Journal:  Medicina (Kaunas)       Date:  2020-03-16       Impact factor: 2.430

7.  Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro.

Authors:  Mei Tong He; Ah Young Lee; Chan Hum Park; Eun Ju Cho
Journal:  Nutr Res Pract       Date:  2019-07-10       Impact factor: 1.926
  7 in total

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