Literature DB >> 25211851

Beta blocker eye drops for treatment of acute migraine.

Carl V Migliazzo, John C Hagan.   

Abstract

We report seven cases of successful treatment of acute migraine symptoms using beta blocker eye drops. The literature on beta blockers for acute migraine is reviewed. Oral beta blocker medication is not effective for acute migraine treatment. This is likely due to a relatively slow rate of achieving therapeutic plasma levels when taken orally. Topical beta blocker eye drops achieve therapeutic plasma levels within minutes of ocular administration which may explain their apparent effectiveness in relief of acute migraine symptoms.

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Year:  2014        PMID： 25211851      PMCID： PMC6179466     

Source DB:  PubMed          Journal:  Mo Med        ISSN： 0026-6620


  13 in total

1.  Topical beta-blocker treatment for migraine.

Authors:  Patrick J T Chiam
Journal:  Int Ophthalmol       Date:  2012-01-26       Impact factor: 2.031

2.  The possible treatment of migraine with carteolol hydrochloride.

Authors:  M K Shapiro; R Gorn
Journal:  Headache       Date:  1999-02       Impact factor: 5.887

3.  Incidence and determinants of migraine prophylactic medication in the Netherlands.

Authors:  H Rahimtoola; H Buurma; C C Tijssen; H G Leufkens; A C G Egberts
Journal:  Eur J Clin Pharmacol       Date:  2002-04-05       Impact factor: 2.953

4.  Propranolol in acute migraine: a controlled study.

Authors:  G N Fuller; R J Guiloff
Journal:  Cephalalgia       Date:  1990-10       Impact factor: 6.292

5.  Pharmacokinetic and pharmacodynamic analysis of systemic effect of topically applied timolol maleate ophthalmic gelling vehicle (Rysmon TG).

Authors:  Yoshiyuki Ohno; Tatuji Iga; Yasuhiko Yamada; Miyuki Nagahara; Makoto Araie; Risa Takayanagi
Journal:  Curr Eye Res       Date:  2005-04       Impact factor: 2.424

6.  A Pediatric Case of Ophthalmoplegic Migraine with Recurrent Oculomotor Nerve Palsy.

Authors: 
Journal:  Jpn J Ophthalmol       Date:  2000-09-01       Impact factor: 2.447

7.  Timolol. A beta-adrenergic blocking agent for the treatment of glaucoma.

Authors:  T J Zimmerman; H E Kaufman
Journal:  Arch Ophthalmol       Date:  1977-04

Review 8.  First-pass elimination. Basic concepts and clinical consequences.

Authors:  S M Pond; T N Tozer
Journal:  Clin Pharmacokinet       Date:  1984 Jan-Feb       Impact factor: 6.447

Review 9.  Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects.

Authors:  T Nieminen; T Lehtimäki; J Mäenpää; A Ropo; H Uusitalo; M Kähönen
Journal:  Scand J Clin Lab Invest       Date:  2007       Impact factor: 1.713

10.  Propranolol in the treatment of acute migraine attacks.

Authors:  M Banerjee; L Findley
Journal:  Cephalalgia       Date:  1991-09       Impact factor: 6.292
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  4 in total

1.  Timolol Eyedrops in the Treatment of Acute Migraine Attacks: A Randomized Crossover Study.

Authors:  Matthew Cossack; Edward Nabrinsky; Heath Turner; Ashley Abraham; Sean Gratton
Journal:  JAMA Neurol       Date:  2018-08-01       Impact factor: 18.302

2.  Migraine relief in 20 minutes using eyedrops?

Authors:  Yufei Ge; Gregory Castelli
Journal:  J Fam Pract       Date:  2022-06       Impact factor: 0.725

3.  It Should Not Be This Difficult to Engage Pharma in an Effective, Safe, Inexpensive Product for Acute Migraine, the Third Most Prevalent Disease in the World.

Authors:  John C Hagan
Journal:  Mo Med       Date:  2022 Jan-Feb

4.  A Randomized, Double-Blinded, Placebo-Controlled, Cross Over Study Evaluating the Efficacy and Safety of Timolol Ophthalmic Solution as an Acute Treatment of Migraine.

Authors:  Dipika Aggarwal; Andrew J Heim; Brennen Bittel; Deetra Ford; Richard Dubinsky; Gary Gronseth; Vernita Hairston; Patrick Landazuri; Fred Sachen; Laura Herbelin; Richard J Barohn
Journal:  Kans J Med       Date:  2020-02-26
  4 in total

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