Isabella Soreca1. 1. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Abstract
PURPOSE OF REVIEW: Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. RECENT FINDINGS: Patients with bipolar disorder show altered rhythmicity in body temperature and melatonin rhythms, high day-to-day variability in activity and sleep timing, persistent disturbances of sleep or wake cycles, including disturbances of sleep continuity. The internal clocks are, indeed, responsible for regulating a variety of physiologic functions, including appetitive behaviors, cognitive functions and metabolism. SUMMARY: An underlying circadian pathology in bipolar disorder is a unifying explicatory model for the high psychiatric and medical comorbidity observed during the long-term course of the disorder. This model also provides a rationale for therapeutic interventions aimed at re-entraining the internal clock.
PURPOSE OF REVIEW: Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. RECENT FINDINGS:Patients with bipolar disorder show altered rhythmicity in body temperature and melatonin rhythms, high day-to-day variability in activity and sleep timing, persistent disturbances of sleep or wake cycles, including disturbances of sleep continuity. The internal clocks are, indeed, responsible for regulating a variety of physiologic functions, including appetitive behaviors, cognitive functions and metabolism. SUMMARY: An underlying circadian pathology in bipolar disorder is a unifying explicatory model for the high psychiatric and medical comorbidity observed during the long-term course of the disorder. This model also provides a rationale for therapeutic interventions aimed at re-entraining the internal clock.
Authors: Paulo Marcos Brasil Rocha; Simone Becho Campos; Fernando Silva Neves; Humberto Corrêa da Silva Filho Journal: Psychiatry Investig Date: 2017-09-11 Impact factor: 2.505
Authors: Wallace C Duncan; Elizabeth E Slonena; Nadia S Hejazi; Nancy Brutsche; Lawrence T Park; Ioline D Henter; Elizabeth D Ballard; Carlos A Zarate Journal: Neuropsychiatr Dis Treat Date: 2018-10-16 Impact factor: 2.570
Authors: Joseph W S Timothy; Natasza Klas; Harshmeena R Sanghani; Taghreed Al-Mansouri; Alun T L Hughes; Greer S Kirshenbaum; Vincent Brienza; Mino D C Belle; Martin R Ralph; Steven J Clapcote; Hugh D Piggins Journal: Biol Psychiatry Date: 2017-05-20 Impact factor: 13.382