Hélem de Sena Ribeiro1, Lucilene Rezende Anastácio2, Lívia Garcia Ferreira3, Erika Barbosa Lagares4, Agnaldo Soares Lima5, Maria Isabel Toulson Davisson Correia5. 1. Postgraduate Program in Food Science, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. 2. Postgraduate Program in Adult Health, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. 3. Postgraduate Program in Sciences applied to Surgery and Ophthalmology, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. 4. University of Itaúna, Itaúna, MG, Brazil. 5. Alfa Institute of Gastroenterology, Hospital das Clínicas, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Abstract
OBJECTIVE: to determine the prevalence of abnormal total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides in patients undergoing liver transplantation (LTx) and to identify predictors of these disorders. METHODS: cross-sectional study to assess the prevalence of dyslipidemia in patients undergoing LTx. Demographic, socioeconomic, clinical, anthropometric and dietetic data were collected to determine the association with dyslipidemia using univariate and multivariate statistical analysis. RESULTS: 136 patients were evaluated, 68.1% of which had at least one type of dyslipidemia. The triglyceride level was high in 32.4% of cases, with low HDL in 49.3% of patients and high LDL levels in only 8.8%. High total cholesterol was observed in 16.2% of the study population and was associated with the recommendation for transplantation due to ethanolic cirrhosis (OR = 2.7) and a greater number of hours slept per night (OR = 1.5). CONCLUSION: many patients presented dyslipidemia after transplantation, demonstrating the need for interventions in relation to modifiable factors associated with dyslipidemias that can mitigate or prevent these disorders.
OBJECTIVE: to determine the prevalence of abnormal total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides in patients undergoing liver transplantation (LTx) and to identify predictors of these disorders. METHODS: cross-sectional study to assess the prevalence of dyslipidemia in patients undergoing LTx. Demographic, socioeconomic, clinical, anthropometric and dietetic data were collected to determine the association with dyslipidemia using univariate and multivariate statistical analysis. RESULTS: 136 patients were evaluated, 68.1% of which had at least one type of dyslipidemia. The triglyceride level was high in 32.4% of cases, with low HDL in 49.3% of patients and high LDL levels in only 8.8%. High total cholesterol was observed in 16.2% of the study population and was associated with the recommendation for transplantation due to ethanolic cirrhosis (OR = 2.7) and a greater number of hours slept per night (OR = 1.5). CONCLUSION: many patients presented dyslipidemia after transplantation, demonstrating the need for interventions in relation to modifiable factors associated with dyslipidemias that can mitigate or prevent these disorders.
Authors: Kevin K W Chu; See Ching Chan; Sui Ling Sin; Albert C Y Chan; Kenneth S H Chok; Ignatius K P Cheng; Chung Mau Lo Journal: Hepatol Int Date: 2017-02-07 Impact factor: 6.047