CONTEXT: Non-Hodgkin's lymphomas (NHL) primarily involving the orbit, is relatively uncommon. Rarely two pathologically different NHL cell types have been found to be coexistent. CASE REPORT: We report a case of orbital lymphoma in a 62-year-old male with rare histopathological findings secondary to transformation of once cell type into another. Tissue diagnosis and molecular studies led to revelation of diffuse large B cell lymphoma evolving from MALT lymphoma. CONCLUSION: Proliferation of two morphologically and phenotypically different B cells resulting in malignancy has not been found in the orbit so far. They are usually aggressive tumors and require chemo-immunotherapy.
CONTEXT: Non-Hodgkin's lymphomas (NHL) primarily involving the orbit, is relatively uncommon. Rarely two pathologically different NHL cell types have been found to be coexistent. CASE REPORT: We report a case of orbital lymphoma in a 62-year-old male with rare histopathological findings secondary to transformation of once cell type into another. Tissue diagnosis and molecular studies led to revelation of diffuse large B cell lymphoma evolving from MALT lymphoma. CONCLUSION: Proliferation of two morphologically and phenotypically different B cells resulting in malignancy has not been found in the orbit so far. They are usually aggressive tumors and require chemo-immunotherapy.
Entities:
Keywords:
Diffuse large B cell lymphoma; Marginal zone mucosa-associated lymphoid tissue lymphoma; Orbital lymphoma; Rituximab
Authors: A H Meyer; A Stroux; K Lerch; J Eucker; J Eitle; K Hohloch; M Andrzejak; K Possinger; B Dörken; A Pezzutto; C W Scholz Journal: Ann Oncol Date: 2014-01 Impact factor: 32.976
Authors: Lene D Sjö; Elisabeth Ralfkiaer; Jan U Prause; Jorgen H Petersen; Jakob Madsen; Niels T Pedersen; Steffen Heegaard Journal: Invest Ophthalmol Vis Sci Date: 2008-04-04 Impact factor: 4.799