| Literature DB >> 2521055 |
R A O'Connell1, R L Van Heertum, S B Billick, A R Holt, A Gonzalez, H Notardonato, D Luck, L N King.
Abstract
Single photon emission computed tomography (SPECT) with [123I]N-isopropyl iodoamphetamine--[123I]IMP--was used to study regional cerebral blood flow (rCBF) in 94 psychiatric patients and six controls. Patients with dementias had distinct brain-image patterns, consistent with the expected neuropathology. Major depressives had decreased cortical and subcortical rCBF. Increased caudate rCBF was observed in schizophrenics and other psychoses with positive symptoms. SPECT is a practical method of functional brain imaging with potential in the differential diagnosis of neuropsychiatric disorders. Further studies are needed to assess the effect of other variables on brain-image patterns.Entities:
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Year: 1989 PMID： 2521055 DOI： 10.1176/jnp.1.2.145
Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198