Literature DB >> 25210527

Retinal degeneration in animal models with a defective visual cycle.

Akiko Maeda1, Krzysztof Palczewski2.   

Abstract

Continuous generation of visual chromophore through the visual (retinoid) cycle is essential to maintain eyesight and retinal heath. Impairments in this cycle and related pathways adversely affect vision. In this review, we summarize the chemical reactions of vitamin A metabolites involved in the retinoid cycle and describe animal models of associated human diseases. Development of potential therapies for retinal disorders in these animal models is also introduced.

Entities:  

Year:  2013        PMID： 25210527      PMCID： PMC4157753          DOI： 10.1016/j.ddmod.2014.01.001

Source DB:  PubMed          Journal:  Drug Discov Today Dis Models        ISSN： 1740-6757


  92 in total

1.  Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa.

Authors:  M A Maw; B Kennedy; A Knight; R Bridges; K E Roth; E J Mani; J K Mukkadan; D Nancarrow; J W Crabb; M J Denton
Journal:  Nat Genet       Date:  1997-10       Impact factor: 38.330

2.  RPE65 is the isomerohydrolase in the retinoid visual cycle.

Authors:  Gennadiy Moiseyev; Ying Chen; Yusuke Takahashi; Bill X Wu; Jian-Xing Ma
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-22       Impact factor: 11.205

3.  The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

Authors:  A Wenzel; C E Reme; T P Williams; F Hafezi; C Grimm
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

4.  Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo.

Authors:  Anne Kasus-Jacobi; Jiafu Ou; David G Birch; Kirsten G Locke; John M Shelton; James A Richardson; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Albert O Edwards
Journal:  J Biol Chem       Date:  2005-03-24       Impact factor: 5.157

5.  Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

Authors:  Timothy E Graham; Qin Yang; Matthias Blüher; Ann Hammarstedt; Theodore P Ciaraldi; Robert R Henry; Christopher J Wason; Andreas Oberbach; Per-Anders Jansson; Ulf Smith; Barbara B Kahn
Journal:  N Engl J Med       Date:  2006-06-15       Impact factor: 91.245

6.  Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.

Authors:  Akiko Maeda; Tadao Maeda; Yoshikazu Imanishi; Marcin Golczak; Alexander R Moise; Krzysztof Palczewski
Journal:  Biochemistry       Date:  2006-04-04       Impact factor: 3.162

7.  Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA).

Authors:  Ji-Jing Pang; Bo Chang; Norman L Hawes; Ronald E Hurd; Muriel T Davisson; Jie Li; Syed M Noorwez; Ritu Malhotra; J Hugh McDowell; Shalesh Kaushal; William W Hauswirth; Steven Nusinowitz; Debra A Thompson; John R Heckenlively
Journal:  Mol Vis       Date:  2005-02-28       Impact factor: 2.367

8.  Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.

Authors:  Alberto Ruiz; Manuel Mark; Hugues Jacobs; Muriel Klopfenstein; Jane Hu; Marcia Lloyd; Samer Habib; Chinatsu Tosha; Roxana A Radu; Norbert B Ghyselinck; Steven Nusinowitz; Dean Bok
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-05-17       Impact factor: 4.799

9.  A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.

Authors:  Nicoleta Dobri; Qiong Qin; Jian Kong; Kazunori Yamamoto; Zhao Liu; Gennadiy Moiseyev; Jian-Xing Ma; Rando Allikmets; Janet R Sparrow; Konstantin Petrukhin
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-01-07       Impact factor: 4.799

10.  Retinopathy in mice induced by disrupted all-trans-retinal clearance.

Authors:  Akiko Maeda; Tadao Maeda; Marcin Golczak; Krzysztof Palczewski
Journal:  J Biol Chem       Date:  2008-07-25       Impact factor: 5.157
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  9 in total

Review 1.  Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders.

Authors:  Yu Chen; Krzysztof Palczewski
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-03-23       Impact factor: 13.820

2.  Cholesterol homeostasis in the retina: seeing is believing.

Authors:  Steven J Fliesler
Journal:  J Lipid Res       Date:  2014-11-24       Impact factor: 5.922

3.  Serum levels of lipid metabolites in age-related macular degeneration.

Authors:  Tivadar Orban; William M Johnson; Zhiqian Dong; Tadao Maeda; Akiko Maeda; Tsutomu Sakai; Hiroshi Tsuneoka; John J Mieyal; Krzysztof Palczewski
Journal:  FASEB J       Date:  2015-07-17       Impact factor: 5.191

4.  Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage.

Authors:  Yan Li; Shirley Yu; Todd Duncan; Yichao Li; Pinghu Liu; Erelda Gene; Yoel Cortes-Pena; Haohua Qian; Lijin Dong; T Michael Redmond
Journal:  Hum Mol Genet       Date:  2015-05-13       Impact factor: 6.150

5.  Chemistry and biology of the initial steps in vision: the Friedenwald lecture.

Authors:  Krzysztof Palczewski
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-10-22       Impact factor: 4.799

6.  Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy.

Authors:  Robin Sharma; Christina Schwarz; Jennifer J Hunter; Grazyna Palczewska; Krzysztof Palczewski; David R Williams
Journal:  Invest Ophthalmol Vis Sci       Date:  2017-01-01       Impact factor: 4.799

7.  A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish.

Authors:  Ashish K Solanki; Altaf A Kondkar; Joseph Fogerty; Yanhui Su; Seok-Hyung Kim; Joshua H Lipschutz; Deepak Nihalani; Brian D Perkins; Glenn P Lobo
Journal:  Cells       Date:  2020-04-29       Impact factor: 6.600

8.  Is There an Optimal Combination of AREDS2 Antioxidants Zeaxanthin, Vitamin E and Vitamin C on Light-Induced Toxicity of Vitamin A Aldehyde to the Retina?

Authors:  Małgorzata B Różanowska; Barbara Czuba-Pełech; Bartosz Różanowski
Journal:  Antioxidants (Basel)       Date:  2022-06-09

9.  Improvement in vision: a new goal for treatment of hereditary retinal degenerations.

Authors:  Samuel G Jacobson; Artur V Cideciyan; Gustavo D Aguirre; Alejandro J Roman; Alexander Sumaroka; William W Hauswirth; Krzysztof Palczewski
Journal:  Expert Opin Orphan Drugs       Date:  2015-05-04       Impact factor: 0.694
  9 in total

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