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Literature DB >> 25210416

Drug-gene interactions: inherent variability in drug maintenance dose requirements.

Paul Westervelt, Kihoon Cho, David R Bright, David F Kisor.

Abstract

The influence of genetics on pharmacokinetics can introduce variability among individual patients that may cause treatment failure, toxicity, or both. Such variability, specifically in clearance rates, can influence drug maintenance dosing regimens.

Entities: Disease Species

Keywords: dosing interval; drug–gene interaction; maintenance dose; pharmacogenetics

Year: 2014 PMID： 25210416 PMCID： PMC4159057

Source DB: PubMed Journal: P T ISSN： 1052-1372

46 in total

1. Evaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450: focus on cytochrome P450 2C19.

Authors: Tatyana Zvyaga; Shu-Ying Chang; Cliff Chen; Zheng Yang; Ragini Vuppugalla; Jeremy Hurley; Denise Thorndike; Andrew Wagner; Anjaneya Chimalakonda; A David Rodrigues
Journal: Drug Metab Dispos Date: 2012-05-30 Impact factor: 3.922

2. Vanderbilt pioneers bedside genetics.

Authors: Bob Carlson
Journal: Biotechnol Healthc Date: 2012

3. Association of CYP2C9 polymorphisms with phenytoin toxicity in Indian patients.

Authors: Akanksha N Thakkar; Shital R Bendkhale; Santosh R Taur; Nithya J Gogtay; Urmila M Thatte
Journal: Neurol India Date: 2012 Nov-Dec Impact factor: 2.117

4. A pharmacogenetic versus a clinical algorithm for warfarin dosing.

Authors: Stephen E Kimmel; Benjamin French; Scott E Kasner; Julie A Johnson; Jeffrey L Anderson; Brian F Gage; Yves D Rosenberg; Charles S Eby; Rosemary A Madigan; Robert B McBane; Sherif Z Abdel-Rahman; Scott M Stevens; Steven Yale; Emile R Mohler; Margaret C Fang; Vinay Shah; Richard B Horenstein; Nita A Limdi; James A S Muldowney; Jaspal Gujral; Patrice Delafontaine; Robert J Desnick; Thomas L Ortel; Henny H Billett; Robert C Pendleton; Nancy L Geller; Jonathan L Halperin; Samuel Z Goldhaber; Michael D Caldwell; Robert M Califf; Jonas H Ellenberg
Journal: N Engl J Med Date: 2013-11-19 Impact factor: 91.245

5. Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.

Authors: Issam Zineh; Amber L Beitelshees; Andrea Gaedigk; Joseph R Walker; Daniel F Pauly; Kathleen Eberst; J Steven Leeder; Michael S Phillips; Craig A Gelfand; Julie A Johnson
Journal: Clin Pharmacol Ther Date: 2004-12 Impact factor: 6.875

6. Clopidogrel: a case for indication-specific pharmacogenetics.

Authors: J A Johnson; D M Roden; L J Lesko; E Ashley; T E Klein; A R Shuldiner
Journal: Clin Pharmacol Ther Date: 2012-05 Impact factor: 6.875

7. Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites.

Authors: Julia Kirchheiner; Elke Störmer; Christian Meisel; Nadine Steinbach; Ivar Roots; Jürgen Brockmöller
Journal: Pharmacogenetics Date: 2003-08

8. Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study.

Authors: T Rau; H Wuttke; L M Michels; U Werner; K Bergmann; M Kreft; M F Fromm; T Eschenhagen
Journal: Clin Pharmacol Ther Date: 2008-11-26 Impact factor: 6.875

Review 9. Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues.

Authors: Brian F Gage; Lawrence J Lesko
Journal: J Thromb Thrombolysis Date: 2007-10-01 Impact factor: 2.300

Review 10. Cytochrome p450 and chemical toxicology.

Authors: F Peter Guengerich
Journal: Chem Res Toxicol Date: 2007-12-06 Impact factor: 3.739

3 in total

Review 1. Precision medicine for rheumatologists: lessons from the pharmacogenomics of azathioprine.

Authors: Laura L Daniel; Alyson L Dickson; Cecilia P Chung
Journal: Clin Rheumatol Date: 2020-07-02 Impact factor: 2.980

2. Impact of Drug-Gene-Interaction, Drug-Drug-Interaction, and Drug-Drug-Gene-Interaction on (es)Citalopram Therapy: The PharmLines Initiative.

Authors: Muh Akbar Bahar; Pauline Lanting; Jens H J Bos; Rolf H Sijmons; Eelko Hak; Bob Wilffert
Journal: J Pers Med Date: 2020-11-28

3. Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics.

Authors: Maria Koromina; Stefania Koutsilieri; George P Patrinos
Journal: Hum Genomics Date: 2020-01-15 Impact factor: 4.639

3 in total