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Literature DB >> 25209733

Super-soft hydrogel particles with tunable elasticity in a microfluidic blood capillary model.

Jiwei Cui¹, Mattias Björnmalm, Kang Liang, Chenglong Xu, James P Best, Xuehua Zhang, Frank Caruso.

Abstract

Super-soft PEG hydrogel particles with tunable elasticity are prepared via a mesoporous silica templating method. The deformability behavior of these particles, in a microfluidic blood-capillary model, can be tailored to be similar to that of human red blood cells. These results provide a new platform for the design and development of soft hydrogel particles for investigating bio-nano interactions.

Entities: Chemical Species

Keywords: PEG hydrogel particles; atomic force microscopy; elasticity; mesoporous silica particles; microfluidic model

Mesh：

Substances：

Year: 2014 PMID： 25209733 DOI： 10.1002/adma.201402753

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

17 in total

1. Vascular-targeted particle binding efficacy in the presence of rigid red blood cells: Implications for performance in diseased blood.

Authors: Mario Gutierrez; Lauro Sebastian Ojeda; Omolola Eniola-Adefeso
Journal: Biomicrofluidics Date: 2018-06-25 Impact factor: 2.800

2. Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better.

Authors: Margaret B Fish; Catherine A Fromen; Genesis Lopez-Cazares; Alexander W Golinski; Timothy F Scott; Reheman Adili; Michael Holinstat; Omolola Eniola-Adefeso
Journal: Biomaterials Date: 2017-02-04 Impact factor: 12.479

3. Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration.

Authors: Stephanie M Kong; Daniel F Costa; Anna Jagielska; Krystyn J Van Vliet; Paula T Hammond
Journal: Proc Natl Acad Sci U S A Date: 2021-10-19 Impact factor: 11.205

4. Shape-Dependent Biodistribution of Biocompatible Silk Microcapsules.

Authors: Sisi Cao; Rui Tang; Gail Sudlow; Zheyu Wang; Keng-Ku Liu; Jingyi Luan; Sirimuvva Tadepalli; Anushree Seth; Samuel Achilefu; Srikanth Singamaneni
Journal: ACS Appl Mater Interfaces Date: 2019-01-28 Impact factor: 9.229

5. Biodistribution Analysis of NIR-Labeled Nanogels Using in Vivo FMT Imaging in Triple Negative Human Mammary Carcinoma Models.

Authors: Mallory R Gordon; Jiaming Zhuang; Judy Ventura; Longyu Li; Kishore Raghupathi; S Thayumanavan
Journal: Mol Pharm Date: 2018-02-12 Impact factor: 4.939

Super-soft hydrogel particles with tunable elasticity in a microfluidic blood capillary model.

1. Vascular-targeted particle binding efficacy in the presence of rigid red blood cells: Implications for performance in diseased blood.

2. Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better.

3. Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration.

4. Shape-Dependent Biodistribution of Biocompatible Silk Microcapsules.

5. Biodistribution Analysis of NIR-Labeled Nanogels Using in Vivo FMT Imaging in Triple Negative Human Mammary Carcinoma Models.

6. Principles of nanoparticle design for overcoming biological barriers to drug delivery.

7. Flow of Tunable Elastic Microcapsules through Constrictions.

Review 8. Blood Particulate Analogue Fluids: A Review.

Review 9. Use of Protamine in Nanopharmaceuticals-A Review.

10. Shape-Preserved Transformation of Biological Cells into Synthetic Hydrogel Microparticles.