Literature DB >> 25209617

Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies.

L M Reyes1, R J Blosser, R F Smith, A C Miner, L L Paris, R L Blankenship, M F Tector, A J Tector.   

Abstract

We have characterized swine leucocyte antigen (SLA) classes I and II molecules of a domestic pig as a model for use in our xenotransplant program. Molecular characterization of the SLA classes I and II genes is critical to understanding the adaptive immune responses between swine and humans in the event of xenotransplantation. Seven swine leucocyte antigen genes (SLA-1, SLA-2, SLA-3, DQB1, DRB1, DQA and DRA) were analyzed and 15 alleles were identified. A novel DRA*w04re01 is reported for this limited polymorphic class II gene. The heterozygous haplotypes, Hp-32.0/35.0 and Hp-0.13/0.23 were deduced for our IU-pig model, for SLA classes I and II regions, respectively.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Sus scrofa; genotyping; haplotypes; polymorphism; swine leucocyte antigen; xenotransplantation

Mesh：

Substances：

Year:  2014        PMID： 25209617     DOI： 10.1111/tan.12430

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  7 in total

1.  Swine Leukocyte Antigen Class II Is a Xenoantigen.

Authors:  Joseph M Ladowski; Luz M Reyes; Gregory R Martens; James R Butler; Zheng-Yu Wang; Devin E Eckhoff; Matthew Tector; A Joseph Tector
Journal:  Transplantation       Date:  2018-02       Impact factor: 4.939

2.  Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease.

Authors:  Luz M Reyes; Jose L Estrada; Zheng Yu Wang; Rachel J Blosser; Rashod F Smith; Richard A Sidner; Leela L Paris; Ross L Blankenship; Caitlin N Ray; Aaron C Miner; Matthew Tector; A Joseph Tector
Journal:  J Immunol       Date:  2014-10-22       Impact factor: 5.422

3.  Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens.

Authors:  Joseph M Ladowski; Gregory R Martens; Luz M Reyes; Vera Hauptfeld-Dolejsek; Matthew Tector; Joseph Tector
Journal:  Immunogenetics       Date:  2019-07-04       Impact factor: 2.846

4.  Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins.

Authors:  Joseph M Ladowski; Gregory R Martens; Luz M Reyes; Zheng-Yu Wang; Devin E Eckhoff; Vera Hauptfeld-Dolejsek; Matt Tector; A Joseph Tector
Journal:  J Immunol       Date:  2018-03-14       Impact factor: 5.422

5.  Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs.

Authors:  Caixia Gao; Jinqiang Quan; Xinjie Jiang; Changwen Li; Xiaoye Lu; Hongyan Chen
Journal:  Front Immunol       Date:  2017-03-15       Impact factor: 7.561

6.  Analysis of swine leukocyte antigen class I gene profiles and porcine endogenous retrovirus viremia level in a transgenic porcine herd inbred for xenotransplantation research.

Authors:  Daria Matczyńska; Daniel Sypniewski; Sabina Gałka; Dagna Sołtysik; Tomasz Loch; Ewa Nowak; Zdzisław Smorąg; Ilona Bednarek
Journal:  J Vet Sci       Date:  2018-05-31       Impact factor: 1.672

7.  Effect of Genetic Diversity in Swine Leukocyte Antigen-DRA Gene on Piglet Diarrhea.

Authors:  Xiaoyu Huang; Qiaoli Yang; Junhu Yuan; Lixia Liu; Wenyang Sun; Yingdi Jiang; Shengguo Zhao; Shengwei Zhang; Wangzhou Huang; Shuangbao Gun
Journal:  Genes (Basel)       Date:  2016-07-15       Impact factor: 4.096
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.