Eleonore Savatovsky1, Jean-Claude Mwanza2, Donald L Budenz3, William J Feuer1, Ruth Vandenbroucke1, Joyce C Schiffman1, Douglas R Anderson1. 1. Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida. 2. Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 3. Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: donald_budenz@med.unc.edu.
Abstract
PURPOSE: To explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma. DESIGN: Prospective, longitudinal cohort study of cases and controls. PARTICIPANTS: We included 279 age-matched and follow-up time-matched eyes with OHT that converted to glaucoma and 279 eyes with OHT that did not convert to glaucoma. METHODS: Initial and last acceptable optic disc photos were analyzed. Disc, α-zone, and β-zone PPA were traced independently by 2 trained readers and their areas were measured with Photoshop. The α-zone and β-zone areas were expressed as a percentage of optic disc area. MAIN OUTCOME MEASURES: α-Zone and β-zone PPA size over time. RESULTS: Intraclass correlation coefficients (ICCs) demonstrated that readers had good agreement on disc area (ICC = 0.97) and β-zone (ICC = 0.82), but not α-zone (ICC = 0.48). The ß-zone, as a percentage of disc area, increased in size (P < 0.001) in both eyes with incident primary open-angle glaucoma (mean, 10.6%; standard deviation, 22.6%) and matched controls (mean, 10.1%; standard deviation, 33.7) over follow-up (mean, 12.3 years). The increase in size did not differ between cases and controls (P = 0.82). Enlargement of the β-zone was not correlated with follow-up time (P = 0.39). CONCLUSIONS: The results did not show a difference in size of the β-zone at baseline between eyes that proceed to develop glaucoma and those that do not. Moreover, the β-zone enlarges equally in case and control eyes during follow-up.
PURPOSE: To explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma. DESIGN: Prospective, longitudinal cohort study of cases and controls. PARTICIPANTS: We included 279 age-matched and follow-up time-matched eyes with OHT that converted to glaucoma and 279 eyes with OHT that did not convert to glaucoma. METHODS: Initial and last acceptable optic disc photos were analyzed. Disc, α-zone, and β-zone PPA were traced independently by 2 trained readers and their areas were measured with Photoshop. The α-zone and β-zone areas were expressed as a percentage of optic disc area. MAIN OUTCOME MEASURES: α-Zone and β-zone PPA size over time. RESULTS: Intraclass correlation coefficients (ICCs) demonstrated that readers had good agreement on disc area (ICC = 0.97) and β-zone (ICC = 0.82), but not α-zone (ICC = 0.48). The ß-zone, as a percentage of disc area, increased in size (P < 0.001) in both eyes with incident primary open-angle glaucoma (mean, 10.6%; standard deviation, 22.6%) and matched controls (mean, 10.1%; standard deviation, 33.7) over follow-up (mean, 12.3 years). The increase in size did not differ between cases and controls (P = 0.82). Enlargement of the β-zone was not correlated with follow-up time (P = 0.39). CONCLUSIONS: The results did not show a difference in size of the β-zone at baseline between eyes that proceed to develop glaucoma and those that do not. Moreover, the β-zone enlarges equally in case and control eyes during follow-up.
Authors: Young H Kwon; Young I Kim; Mary Lucy M Pereira; Paul R Montague; M Bridget Zimmerman; Wallace L M Alward Journal: J Glaucoma Date: 2003-10 Impact factor: 2.503
Authors: C Gustavo De Moraes; James T Murphy; Chad M Kaplan; Jeremy J Reimann; Alon Skaat; Dana M Blumberg; Lama Al-Aswad; George A Cioffi; Christopher A Girkin; Felipe A Medeiros; Robert N Weinreb; Linda Zangwill; Jeffrey M Liebmann Journal: JAMA Ophthalmol Date: 2017-06-01 Impact factor: 7.389
Authors: Anton M Kolomeyer; Eli Smith; Ebenezer Daniel; Gui-Shuang Ying; Wei Pan; Max Pistilli; Juan Grunwald; Maureen G Maguire; Benjamin J Kim Journal: Retina Date: 2021-01-01 Impact factor: 3.975
Authors: Joseph L Demer; Robert A Clark; Soh Youn Suh; JoAnn A Giaconi; Kouros Nouri-Mahdavi; Simon K Law; Laura Bonelli; Anne L Coleman; Joseph Caprioli Journal: Invest Ophthalmol Vis Sci Date: 2017-08-01 Impact factor: 4.799