Alexis C Edwards1, Jon Heron2, Danielle M Dick1, Matt Hickman2, Glyn Lewis3, John Macleod2, Kenneth S Kendler1. 1. Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia. 2. School of Social and Community Medicine, University of Bristol, Bristol, England. 3. Division of Psychiatry, University College London, London, England.
Abstract
OBJECTIVE: Alcohol use and internalizing problems are often positively associated during adolescence and adulthood. However, the basis of this relationship remains poorly understood, and longitudinal data collected in population-based samples could improve the development of etiological models. METHOD: Using a prospective population-based U.K. cohort, the current study examined the relationship between frequency of drinking during adolescence (ages 13-15, N = 7,100) with problems with depression and anxiety at average age 17 years 10 months (n = 4,292). Analyses were conducted separately by sex and adjusted by the inclusion of potential individual- and familial-level confounders. RESULTS: Among boys, drinking frequency was positively associated with later depression but not anxiety. This association was robust to adjustment for covariates/confounders. Among girls, drinking frequency was related to later depression and anxiety in univariable analyses. In multivariable analyses, only the association with depression remained after adjustment for covariates/confounders. RESULTS were comparable across sexes, although the effect size of drinking frequency was higher among boys. CONCLUSIONS: Higher adolescent alcohol use, even at sub-clinical levels, is associated with an increased risk of later problems with depression but may not be associated with an aggregate measure of anxiety. Future research should consider the possibility of differential relationships between multiple measures of adolescent alcohol use and distinct internalizing outcomes later in development.
OBJECTIVE: Alcohol use and internalizing problems are often positively associated during adolescence and adulthood. However, the basis of this relationship remains poorly understood, and longitudinal data collected in population-based samples could improve the development of etiological models. METHOD: Using a prospective population-based U.K. cohort, the current study examined the relationship between frequency of drinking during adolescence (ages 13-15, N = 7,100) with problems with depression and anxiety at average age 17 years 10 months (n = 4,292). Analyses were conducted separately by sex and adjusted by the inclusion of potential individual- and familial-level confounders. RESULTS: Among boys, drinking frequency was positively associated with later depression but not anxiety. This association was robust to adjustment for covariates/confounders. Among girls, drinking frequency was related to later depression and anxiety in univariable analyses. In multivariable analyses, only the association with depression remained after adjustment for covariates/confounders. RESULTS were comparable across sexes, although the effect size of drinking frequency was higher among boys. CONCLUSIONS: Higher adolescent alcohol use, even at sub-clinical levels, is associated with an increased risk of later problems with depression but may not be associated with an aggregate measure of anxiety. Future research should consider the possibility of differential relationships between multiple measures of adolescent alcohol use and distinct internalizing outcomes later in development.
Authors: Carolyn A McCarty; Rick Kosterman; W Alex Mason; Elizabeth McCauley; J David Hawkins; Todd I Herrenkohl; Liliana J Lengua Journal: Gen Hosp Psychiatry Date: 2009-07-10 Impact factor: 3.238
Authors: Monica A Longmore; Eric E Sevareid; Wendy D Manning; Peggy C Giordano; William Clemens; Heather Taylor Journal: J Youth Adolesc Date: 2021-11-19
Authors: James J Li; Jeanne E Savage; Kenneth S Kendler; Matthew Hickman; Liam Mahedy; John Macleod; Jaakko Kaprio; Richard J Rose; Danielle M Dick Journal: J Stud Alcohol Drugs Date: 2017-05 Impact factor: 2.582
Authors: Qingyu Zhao; Edith V Sullivan; Eva M Műller-Oehring; Nicolas Honnorat; Ehsan Adeli; Simon Podhajsky; Fiona C Baker; Ian M Colrain; Devin Prouty; Susan F Tapert; Sandra A Brown; Mary J Meloy; Ty Brumback; Bonnie J Nagel; Angelica M Morales; Duncan B Clark; Beatriz Luna; Michael D De Bellis; James T Voyvodic; Kate B Nooner; Adolf Pfefferbaum; Kilian M Pohl Journal: Addict Biol Date: 2020-05-19 Impact factor: 4.280