Annelotte Philipsen1, Anne-Louise Smidt Hansen, Marit Eika Jørgensen, Søren Brage, Bendix Carstensen, Annelli Sandbaek, Thomas Peter Almdal, Jeppe Gram, Erling Bjerregaard Pedersen, Torsten Lauritzen, Daniel Rinse Witte. 1. 1Steno Diabetes Center A/S, Gentofte, DENMARK; 2Section of General Medical Practice, Department of Public Health, Aarhus University, Aarhus, DENMARK; 3MRC Epidemiology Unit, University of Cambridge, Cambridge, UNITED KINGDOM; 4Department of Internal Medicine F, Gentofte Hospital, Gentofte, DENMARK; 5Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, DENMARK; 6University Clinic in Nephrology and Hypertension, Department of Medical Research, Holstebro Hospital, Holstebro, DENMARK; 7Department of Public Health, Public Research Center for Health, Strassen, LUXEMBOURG.
Abstract
INTRODUCTION/ PURPOSE: Visceral adipose tissue (VAT) and physical activity are both independent predictors of Type 2 diabetes. Physical activity and overall obesity are inversely associated with each other. Yet the nature of the association between objectively measured dimensions of physical activity and abdominal fat distribution has not been well characterized. We aimed to do so in a middle-age to elderly population at high risk of diabetes. METHODS: A cross-sectional analysis of 1134 participants of the ADDITION-PRO study. VAT and subcutaneous adipose tissue (SAT) were assessed one-dimensionally by ultrasonography and physical activity with combined accelerometry and HR monitoring. Linear regression of physical activity energy expenditure (PAEE) and time spent in different physical activity intensity levels on VAT and SAT was performed. RESULTS: Median body mass index (BMI) was 26.6 kg·m and PAEE was 28.1 kJ·kg·d, with 18.9 h·d spent sedentary, 4.5 h·d in light-intensity physical activity, and 0.4 h·d in moderate-intensity physical activity. PAEE was significantly negatively associated with VAT, and in women, PAEE was also significantly negatively associated with SAT. The difference in VAT was -1.1 mm (95% confidence interval [CI] = -1.8 to -0.3) per 10-kJ·kg·d increment, and the corresponding difference in SAT for women was -0.6 mm (95% CI = -1.2 to -0.04) in models adjusted for age, sex, and waist circumference. Exchanging 1 h of light physical activity with moderate physical activity was significantly associated with VAT (-4.5 mm, 95% CI = -7.6 to -1.5). Exchanging one sedentary hour with light physical activity was significantly associated with both VAT (-0.9 mm, 95% CI = -0.1 to -1.8) and SAT (-0.4 mm, 95% CI = -0.0 to -0.7). CONCLUSIONS: In this population with low physical activity levels, cross-sectional findings indicate that increasing overall physical activity and decreasing time spent sedentary is important to avoid the accumulation of metabolically deleterious VAT.
INTRODUCTION/ PURPOSE: Visceral adipose tissue (VAT) and physical activity are both independent predictors of Type 2 diabetes. Physical activity and overall obesity are inversely associated with each other. Yet the nature of the association between objectively measured dimensions of physical activity and abdominal fat distribution has not been well characterized. We aimed to do so in a middle-age to elderly population at high risk of diabetes. METHODS: A cross-sectional analysis of 1134 participants of the ADDITION-PRO study. VAT and subcutaneous adipose tissue (SAT) were assessed one-dimensionally by ultrasonography and physical activity with combined accelerometry and HR monitoring. Linear regression of physical activity energy expenditure (PAEE) and time spent in different physical activity intensity levels on VAT and SAT was performed. RESULTS: Median body mass index (BMI) was 26.6 kg·m and PAEE was 28.1 kJ·kg·d, with 18.9 h·d spent sedentary, 4.5 h·d in light-intensity physical activity, and 0.4 h·d in moderate-intensity physical activity. PAEE was significantly negatively associated with VAT, and in women, PAEE was also significantly negatively associated with SAT. The difference in VAT was -1.1 mm (95% confidence interval [CI] = -1.8 to -0.3) per 10-kJ·kg·d increment, and the corresponding difference in SAT for women was -0.6 mm (95% CI = -1.2 to -0.04) in models adjusted for age, sex, and waist circumference. Exchanging 1 h of light physical activity with moderate physical activity was significantly associated with VAT (-4.5 mm, 95% CI = -7.6 to -1.5). Exchanging one sedentary hour with light physical activity was significantly associated with both VAT (-0.9 mm, 95% CI = -0.1 to -1.8) and SAT (-0.4 mm, 95% CI = -0.0 to -0.7). CONCLUSIONS: In this population with low physical activity levels, cross-sectional findings indicate that increasing overall physical activity and decreasing time spent sedentary is important to avoid the accumulation of metabolically deleterious VAT.
Authors: Valérie Coats; Jean-Pierre Després; Natalie Alméras; Mickaël Martin; Don D Sin; Rémi Rabasa-Lhoret; Éric Larose; Wan C Tan; Jean Bourbeau; François Maltais Journal: Int J Chron Obstruct Pulmon Dis Date: 2018-10-15
Authors: Robert W Koivula; Naeimeh Atabaki-Pasdar; Giuseppe N Giordano; Tom White; Jerzy Adamski; Jimmy D Bell; Joline Beulens; Søren Brage; Søren Brunak; Federico De Masi; Emmanouil T Dermitzakis; Ian M Forgie; Gary Frost; Torben Hansen; Tue H Hansen; Andrew Hattersley; Tarja Kokkola; Azra Kurbasic; Markku Laakso; Andrea Mari; Timothy J McDonald; Oluf Pedersen; Femke Rutters; Jochen M Schwenk; Harriet J A Teare; E Louise Thomas; Ana Vinuela; Anubha Mahajan; Mark I McCarthy; Hartmut Ruetten; Mark Walker; Ewan Pearson; Imre Pavo; Paul W Franks Journal: Diabetologia Date: 2020-01-30 Impact factor: 10.122
Authors: Aina M Galmes-Panades; Jadwiga Konieczna; Itziar Abete; Antoni Colom; Núria Rosique-Esteban; Maria Angeles Zulet; Zenaida Vázquez; Ramón Estruch; Josep Vidal; Estefanía Toledo; Nancy Babio; Miguel Fiol; Rosa Casas; Josep Vera; Pilar Buil-Cosiales; José Antonio de Paz; Albert Goday; Jordi Salas-Salvadó; J Alfredo Martínez; Dora Romaguera Journal: PLoS One Date: 2019-01-25 Impact factor: 3.240