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Literature DB >> 25207437

Capping protein regulators fine-tune actin assembly dynamics.

Marc Edwards¹, Adam Zwolak², Dorothy A Schafer³, David Sept⁴, Roberto Dominguez², John A Cooper¹.

Abstract

Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates actin assembly by blocking the addition and loss of actin subunits. Recent studies provide new insights into how CP and barbed-end capping are regulated. Filament elongation factors, such as formins and ENA/VASP (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by competing with CP for binding to the barbed end, whereas other molecules, including V-1 and phospholipids, directly bind to CP and sterically block its interaction with the filament. In addition, a diverse and unrelated group of proteins interact with CP through a conserved 'capping protein interaction' (CPI) motif. These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2014 PMID： 25207437 PMCID： PMC4271544 DOI： 10.1038/nrm3869

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

149 in total

1. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.

Authors: T P Loisel; R Boujemaa; D Pantaloni; M F Carlier
Journal: Nature Date: 1999-10-07 Impact factor: 49.962

2. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.

Authors: H Take; S Watanabe; K Takeda; Z X Yu; N Iwata; S Kajigaya
Journal: Biochem Biophys Res Commun Date: 2000-02-16 Impact factor: 3.575

3. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.

Authors: I Gout; G Middleton; J Adu; N N Ninkina; L B Drobot; V Filonenko; G Matsuka; A M Davies; M Waterfield; V L Buchman
Journal: EMBO J Date: 2000-08-01 Impact factor: 11.598

4. CMS: an adapter molecule involved in cytoskeletal rearrangements.

Authors: K H Kirsch; M M Georgescu; S Ishimaru; H Hanafusa
Journal: Proc Natl Acad Sci U S A Date: 1999-05-25 Impact factor: 11.205

5. Acan125 binding to the SH3 domain of acanthamoeba myosin-IC.

Authors: H G Zot; V Bhaskara; L Liu
Journal: Arch Biochem Biophys Date: 2000-03-01 Impact factor: 4.013

6. Organization and ligand binding properties of the tail of Acanthamoeba myosin-IA. Identification of an actin-binding site in the basic (tail homology-1) domain.

Authors: W L Lee; E M Ostap; H G Zot; T D Pollard
Journal: J Biol Chem Date: 1999-12-03 Impact factor: 5.157

7. Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.

Authors: D G Bosc; K C Graham; R B Saulnier; C Zhang; D Prober; R D Gietz; D W Litchfield
Journal: J Biol Chem Date: 2000-05-12 Impact factor: 5.157

8. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.

Authors: S Lehtonen; A Ora; V M Olkkonen; L Geng; M Zerial; S Somlo; E Lehtonen
Journal: J Biol Chem Date: 2000-10-20 Impact factor: 5.157

9. Congenital nephrotic syndrome in mice lacking CD2-associated protein.

Authors: N Y Shih; J Li; V Karpitskii; A Nguyen; M L Dustin; O Kanagawa; J H Miner; A S Shaw
Journal: Science Date: 1999-10-08 Impact factor: 47.728

10. Vertebrate isoforms of actin capping protein beta have distinct functions In vivo.

Authors: M C Hart; J A Cooper
Journal: J Cell Biol Date: 1999-12-13 Impact factor: 10.539

110 in total

1. Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment.

Authors: Alistair Harrison; Laura G Dubois; Lisa St John-Williams; M Arthur Moseley; Rachael L Hardison; Derek R Heimlich; Alexander Stoddard; Joseph E Kerschner; Sheryl S Justice; J Will Thompson; Kevin M Mason
Journal: Mol Cell Proteomics Date: 2015-12-28 Impact factor: 5.911

Capping protein regulators fine-tune actin assembly dynamics.

1. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.

2. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.

3. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.

4. CMS: an adapter molecule involved in cytoskeletal rearrangements.

5. Acan125 binding to the SH3 domain of acanthamoeba myosin-IC.

6. Organization and ligand binding properties of the tail of Acanthamoeba myosin-IA. Identification of an actin-binding site in the basic (tail homology-1) domain.

7. Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.

8. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.

9. Congenital nephrotic syndrome in mice lacking CD2-associated protein.

10. Vertebrate isoforms of actin capping protein beta have distinct functions In vivo.

1. Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment.

Review 2. Plasticity of the brush border - the yin and yang of intestinal homeostasis.

Review 3. Actin Out: Regulation of the Synaptic Cytoskeleton.

4. Regulation of IL-1 signaling through control of focal adhesion assembly.

5. Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity.

Review 6. Function and regulation of the Arp2/3 complex during cell migration in diverse environments.

Review 7. Podocyte-actin dynamics in health and disease.

8. VASP Regulates NK Cell Lytic Granule Convergence.

9. Internetwork competition for monomers governs actin cytoskeleton organization.

10. Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2.