Hamide Sayar1, Sülen Sarıoğlu2, Sevgi Bakariş1, Ilhami Yıldırım3, Hüseyin Oztarakçı4. 1. Department of Pathology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey. 2. Department of Pathology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey. 3. Department of Otolaryngology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey. 4. Department of Otolaryngology, Necip Fazıl Şehir State Hospital, Kahramanmaraş, Turkey.
Abstract
BACKGROUND: High-grade transformation or dedifferentiation in carcinoma is progression of a low-grade malignant neoplasm to a high-grade carcinoma or poorly differentiated adenocarcinoma. This is rarely observed in adenoid cystic carcinoma of the salivary glands. CASE REPORT: A 39 year-old woman presented with a painless mass at the left submandibulary region that had been growing slowly for 5 years. Submandibulary mass resection revealed a mass with peripheral adenoid cystic carcinoma and a central high-grade tumor delineated with a fibrous rim, raising the possibility of a hybrid or composite carcinoma, requiring differential diagnosis depending upon morphology and immunohistochemistry findings. The final histopathological diagnosis was high-grade transformation of adenoid cystic carcinoma. After surgical therapy, the patient was irradiated to the neck and submandibulary region. No sign of tumor recurrence has been evident for 36 months. CONCLUSION: This present case seems to be another rare case with high-grade transformation of adenoid cystic carcinoma and the fibrous rim may be a histopathological feature of such cases, which should be kept in mind.
BACKGROUND: High-grade transformation or dedifferentiation in carcinoma is progression of a low-grade malignant neoplasm to a high-grade carcinoma or poorly differentiated adenocarcinoma. This is rarely observed in adenoid cystic carcinoma of the salivary glands. CASE REPORT: A 39 year-old woman presented with a painless mass at the left submandibulary region that had been growing slowly for 5 years. Submandibulary mass resection revealed a mass with peripheral adenoid cystic carcinoma and a central high-grade tumor delineated with a fibrous rim, raising the possibility of a hybrid or composite carcinoma, requiring differential diagnosis depending upon morphology and immunohistochemistry findings. The final histopathological diagnosis was high-grade transformation of adenoid cystic carcinoma. After surgical therapy, the patient was irradiated to the neck and submandibulary region. No sign of tumor recurrence has been evident for 36 months. CONCLUSION: This present case seems to be another rare case with high-grade transformation of adenoid cystic carcinoma and the fibrous rim may be a histopathological feature of such cases, which should be kept in mind.
Authors: Ana Flávia Costa; Albina Altemani; Hedy Vékony; Elisabeth Bloemena; Florentino Fresno; Carlos Suárez; José Luis Llorente; Mario Hermsen Journal: Cell Oncol (Dordr) Date: 2011-05-04 Impact factor: 6.730
Authors: Raja R Seethala; Jennifer L Hunt; Zubair W Baloch; Virginia A Livolsi; E Leon Barnes Journal: Am J Surg Pathol Date: 2007-11 Impact factor: 6.394
Authors: Henrik Hellquist; Alena Skálová; Leon Barnes; Antonio Cardesa; Lester D R Thompson; Asterios Triantafyllou; Michelle D Williams; Kenneth O Devaney; Douglas R Gnepp; Justin A Bishop; Bruce M Wenig; Carlos Suárez; Juan P Rodrigo; Andrés Coca-Pelaz; Primož Strojan; Jatin P Shah; Marc Hamoir; Patrick J Bradley; Carl E Silver; Pieter J Slootweg; Vincent Vander Poorten; Afshin Teymoortash; Jesus E Medina; K Thomas Robbins; Karen T Pitman; Luiz P Kowalski; Remco de Bree; William M Mendenhall; Jean Anderson Eloy; Robert P Takes; Alessandra Rinaldo; Alfio Ferlito Journal: Adv Ther Date: 2016-02-19 Impact factor: 3.845