Tevfik Ozlu1, Yılmaz Bülbül1, Sezai Taşbakan2, Hatice Kılıç3, Tülin Kuyucu4, Tekin Yıldız5, Tarkan Ozdemir6, Serap Duru7, Funda Oztuna1, Nalan Adıgüzel4, Leyla Sağlam8, Ayşin Şakar Coşkun9, Tacettin Ornek10, Gazi Gündüz11, Ayten Filiz12, Levent Ozdemir13, Gülfer Okumuş14. 1. Department of Chest Diseases, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. 2. Department of Chest Diseases, Faculty of Medicine, Ege University, İzmir, Turkey. 3. Clinic of Chest Diseases, Atatürk Education and Research Hospital, Ankara, Turkey. 4. Clinic of Chest Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey. 5. Department of Chest Diseases, Faculty of Medicine, Dicle University, Diyarbakır, Turkey. 6. Clinic of Chest Diseases, Chest Diseases Hospital, Çorum, Turkey. 7. Clinic of Chest Diseases, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey. 8. Department of Chest Diseases, Faculty of Medicine, Atatürk University, Erzurum, Turkey. 9. Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. 10. Department of Chest Diseases, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. 11. Clinic of Chest Diseases, Dr. Suat Seren Chest Diseases and Thoracic Surgery Education and Research Hospital, İzmir, Turkey. 12. Department of Chest Diseases, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. 13. Clinic of Chest Diseases, Dörtyol State Hospital, Hatay, Turkey. 14. Department of Chest Diseases, Faculty of Medicine, Istanbul University, İstanbul, Turkey.
Abstract
OBJECTIVE: Unlike seasonal influenza, seen in previous years, the strain identified in the 2009 influenza-A pandemic involved high mortality. In this study, prognostic factors and general characteristics of pneumonia cases developed in Turkey during the H1N1 pandemic between October 2009 and January 2010 were analyzed. STUDY DESIGN: Multicenter retrospective study. MATERIAL AND METHODS: This multicentric retrospective study was conducted between August and October 2010 and patients' data were collected by means of standard forms. RESULTS: The study included 264 pneumonia cases, collected from 14 different centers. Mean age was 47.5±18.6 years. Nineteen patients (7.2%) were pregnant or had a new birth and comorbid diseases were detected in 52.3% of all patients. On admission, 35 (13.8%) cases had altered mental status. Overall, 32.6% were treated in intensive care units (ICU) and invasive/non-invasive mechanical ventilation was performed in 29.7%. The mean duration of ICU stay was 2.9±6.2 and total hospital stay was 12.0±9.4 days. Mortality rate was 16.8% (43-cases). The length of ICU treatment, total hospital stay, and mortality were significantly higher in H1N1-confirmed patients. Mortality was significantly higher in patients with dyspnea, cyanosis, and those who had altered mental status on admission. Patients who died had significantly higher rate of peripheral blood neutrophils, lower platelet counts, higher BUN, and lower SaO2 levels. CONCLUSION: This study showed that pneumonia developed during H1N1 pandemic in our country had resulted in a high mortality. Mortality was especially high among patients with cyanosis, altered mental state and those with lower SaO2.
OBJECTIVE: Unlike seasonal influenza, seen in previous years, the strain identified in the 2009 influenza-A pandemic involved high mortality. In this study, prognostic factors and general characteristics of pneumonia cases developed in Turkey during the H1N1 pandemic between October 2009 and January 2010 were analyzed. STUDY DESIGN: Multicenter retrospective study. MATERIAL AND METHODS: This multicentric retrospective study was conducted between August and October 2010 and patients' data were collected by means of standard forms. RESULTS: The study included 264 pneumonia cases, collected from 14 different centers. Mean age was 47.5±18.6 years. Nineteen patients (7.2%) were pregnant or had a new birth and comorbid diseases were detected in 52.3% of all patients. On admission, 35 (13.8%) cases had altered mental status. Overall, 32.6% were treated in intensive care units (ICU) and invasive/non-invasive mechanical ventilation was performed in 29.7%. The mean duration of ICU stay was 2.9±6.2 and total hospital stay was 12.0±9.4 days. Mortality rate was 16.8% (43-cases). The length of ICU treatment, total hospital stay, and mortality were significantly higher in H1N1-confirmed patients. Mortality was significantly higher in patients with dyspnea, cyanosis, and those who had altered mental status on admission. Patients who died had significantly higher rate of peripheral blood neutrophils, lower platelet counts, higher BUN, and lower SaO2 levels. CONCLUSION: This study showed that pneumonia developed during H1N1 pandemic in our country had resulted in a high mortality. Mortality was especially high among patients with cyanosis, altered mental state and those with lower SaO2.
Authors: Rogelio Perez-Padilla; Daniela de la Rosa-Zamboni; Samuel Ponce de Leon; Mauricio Hernandez; Francisco Quiñones-Falconi; Edgar Bautista; Alejandra Ramirez-Venegas; Jorge Rojas-Serrano; Christopher E Ormsby; Ariel Corrales; Anjarath Higuera; Edgar Mondragon; Jose Angel Cordova-Villalobos Journal: N Engl J Med Date: 2009-06-29 Impact factor: 91.245
Authors: Seema Jain; Laurie Kamimoto; Anna M Bramley; Ann M Schmitz; Stephen R Benoit; Janice Louie; David E Sugerman; Jean K Druckenmiller; Kathleen A Ritger; Rashmi Chugh; Supriya Jasuja; Meredith Deutscher; Sanny Chen; John D Walker; Jeffrey S Duchin; Susan Lett; Susan Soliva; Eden V Wells; David Swerdlow; Timothy M Uyeki; Anthony E Fiore; Sonja J Olsen; Alicia M Fry; Carolyn B Bridges; Lyn Finelli Journal: N Engl J Med Date: 2009-10-08 Impact factor: 91.245
Authors: Thomas Bewick; Puja Myles; Sonia Greenwood; Jonathan S Nguyen-Van-Tam; Stephen J Brett; Malcolm G Semple; Peter J Openshaw; Barbara Bannister; Robert C Read; Bruce L Taylor; Jim McMenamin; Joanne E Enstone; Karl G Nicholson; Wei Shen Lim Journal: Thorax Date: 2011-01-20 Impact factor: 9.139