Ahmet Fikret Yücel1, Ozgür Kemik2, Ahu Sarbay Kemik3, Sevim Purisa4, Ishak Sefa Tüzün5. 1. Department of Surgery, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey. 2. Department of Surgery, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey. 3. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey. 4. Department of Biostatistics, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey. 5. Clinic of 2 Surgery, Haseki Education and Research Hospital, İstanbul, Turkey.
Abstract
OBJECTIVE: To explore the differences existing between the levels of oxidative stress in peripheral and mesenteric serum in patients with colorectal cancer. MATERIAL AND METHODS: One hundred fifty patients with colorectal cancer who underwent surgery between May 2005 and March 2010 were prospectively analyzed. The differences between oxidative stress parameters in their peripheral and mesenteric blood were measured. The associations between peripheral and mesenteric levels and the staging and clinicopathological variables were investigated. RESULTS: Oxidative stress parameters were higher in patients with advanced tumor staging (p<0.01), lymph node invasion (p<0.01), and venous invasion (p<0.01). Differences between oxidative stress parameters in peripheral and mesenteric blood samples were also observed. CONCLUSIONS: The mesenteric levels of the oxidative stress markers were higher than the peripheral levels in these colorectal cancer patients. Higher levels of these oxidative stress markers are associated with an advanced state of cancer.
OBJECTIVE: To explore the differences existing between the levels of oxidative stress in peripheral and mesenteric serum in patients with colorectal cancer. MATERIAL AND METHODS: One hundred fifty patients with colorectal cancer who underwent surgery between May 2005 and March 2010 were prospectively analyzed. The differences between oxidative stress parameters in their peripheral and mesenteric blood were measured. The associations between peripheral and mesenteric levels and the staging and clinicopathological variables were investigated. RESULTS: Oxidative stress parameters were higher in patients with advanced tumor staging (p<0.01), lymph node invasion (p<0.01), and venous invasion (p<0.01). Differences between oxidative stress parameters in peripheral and mesenteric blood samples were also observed. CONCLUSIONS: The mesenteric levels of the oxidative stress markers were higher than the peripheral levels in these colorectal cancerpatients. Higher levels of these oxidative stress markers are associated with an advanced state of cancer.
Authors: Víctor Manuel Mendoza-Núñez; Mirna Ruiz-Ramos; Martha A Sánchez-Rodríguez; Raquel Retana-Ugalde; José Luis Muñoz-Sánchez Journal: Tohoku J Exp Med Date: 2007-11 Impact factor: 1.848
Authors: Mohammed Mehdi; M K C Menon; Nebiyou Seyoum; Mahteme Bekele; Wondimagegn Tigeneh; Daniel Seifu Journal: Oxid Med Cell Longev Date: 2018-03-26 Impact factor: 6.543