AIM: To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population. METHODS: A cross-sectional study was performed among subjects who presented for a health examination at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. FLD was diagnosed based on an ultrasonography examination. Serum AFP levels were measured with a chemiluminescence immunoassay. RESULTS: Of the 9800 subjects enrolled, 2601 were diagnosed with FLD. Subjects with FLD had higher serum AFP levels than those without the disease. Subjects with high serum AFP levels had a higher prevalence of FLD, metabolic syndrome, and its components. Univariate logistic analysis showed that elevated serum AFP levels were associated with an increased risk of FLD (OR = 1.057, 95%CI: 1.031-1.084). However, after adjusting for covariates, AFP no longer remained significantly associated with the risk factors for FLD. CONCLUSION: Our results suggest that serum AFP levels are significantly associated with FLD and that AFP acts as a cofactor, but not as an independent factor, for FLD.
AIM: To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population. METHODS: A cross-sectional study was performed among subjects who presented for a health examination at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. FLD was diagnosed based on an ultrasonography examination. Serum AFP levels were measured with a chemiluminescence immunoassay. RESULTS: Of the 9800 subjects enrolled, 2601 were diagnosed with FLD. Subjects with FLD had higher serum AFP levels than those without the disease. Subjects with high serum AFP levels had a higher prevalence of FLD, metabolic syndrome, and its components. Univariate logistic analysis showed that elevated serum AFP levels were associated with an increased risk of FLD (OR = 1.057, 95%CI: 1.031-1.084). However, after adjusting for covariates, AFP no longer remained significantly associated with the risk factors for FLD. CONCLUSION: Our results suggest that serum AFP levels are significantly associated with FLD and that AFP acts as a cofactor, but not as an independent factor, for FLD.
Authors: Min De Zeng; Jian Gao Fan; Lun Gen Lu; You Ming Li; Cheng Wei Chen; Bing Yuan Wang; Yi Min Mao Journal: J Dig Dis Date: 2008-05 Impact factor: 2.325
Authors: Paulo S Ribeiro; Helena Cortez-Pinto; Susana Solá; Rui E Castro; Rita M Ramalho; Amélia Baptista; Miguel C Moura; Maria E Camilo; Cecília M P Rodrigues Journal: Am J Gastroenterol Date: 2004-09 Impact factor: 10.864
Authors: Kelvin Nguyen; Melissa Jimenez; Nima Moghadam; Crystal Wu; Alex Farid; Jonathan Grotts; David Elashoff; Gina Choi; Francisco A Durazo; Mohamed M El-Kabany; Steven-Huy B Han; Sammy Saab Journal: J Clin Transl Hepatol Date: 2017-03-08