| Literature DB >> 25205603 |
Nathalie Douet-Guilbert1, Jean-Richard Eveillard2, Claus Meyer3, Valérie Ugo4, Marie-Josée Le Bris5, Audrey Basinko6, Frédéric Morel1, Rolf Marschalek3, Marc De Braekeleer7.
Abstract
Secondary acute lymphoblastic leukemia (sALL) following chemotherapy and/or radiotherapy of previous malignancies represents 2-10% of all cases of ALL. A 72-year-old female patient was diagnosed with acute lymphoblastic leukemia following chemotherapy for a diffuse large B cell lymphoma. Banding cytogenetics showed a t(t(5;11)(q23-31;q23) in 20 of the 21 metaphases examined and fluorescent in situ hybridization confirmed rearrangement of MLL. Long distance inverse-polymerase chain reaction revealed an in-frame fusion between 5'MLL and 3'PRRC1. Sixty-five cases of sALL associated with 11q23/MLL rearrangement, including 47 with a t(4;11)(q21;q23), were retrieved from the literature. Drug regimen used to treat the primary neoplasm was available for 54 patients; 52 had received a topoisomerase II inhibitor, known to induce MLL rearrangement.Entities:
Keywords: Acute lymphoblastic leukemia; Fusion gene; MLL; PRRC1; Secondary leukemia
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Year: 2014 PMID： 25205603 DOI： 10.1016/j.leukres.2014.08.011
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156