Hsing-Chen Tsai1, Luan-Yin Chang2, Chun-Yi Lu1, Pei-Lan Shao1, Tsui-Yen Fan1, Ai-Ling Cheng1, Jen-Jan Hu3, Shu-Jen Yeh4, Chien-Chih Chang5, Li-Min Huang1. 1. Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. 2. Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: ly7077@tpts6.seed.net.tw. 3. Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan. 4. Department of Pediatrics, Far Eastern Memorial Hospital, New Taipei City, Taiwan. 5. Department of Pediatrics, Min-Sheng General Hospital, Tao-Yuan, Taiwan.
Abstract
BACKGROUND/ PURPOSE: Kawasaki disease (KD) is a disease of unknown cause and the causative agent is most likely to be infectious in nature. To investigate the household transmission pattern of infectious illness and etiology, we thus initiated a prospective case and household study. METHODS: We enrolled KD cases and their household members from February 2004 to September 2008. The KD cases and their household members accepted questionnaire-based interviews of the contact history, signs of infection, and symptoms to check whether clusters of infectious illness occurred. RESULTS: A total of 142 KD cases and 561 household members were enrolled. Among the 142 KD cases, 136 cases (96%) were typical KD, and six (4%) were atypical KD. Of the 561 household members, 17% were siblings, 46% were parents, 18% were grandparents, and the others were cousins or babysitters. Prior to the onset of their KD illness, 66% (94/142) KD cases had contact with ill household members. On the same day of the onset of KD cases' illness, 4% (6/142) KD cases had household members with illness. After KD cases' disease onset, 70% (100/142) KD cases had at least one other family member with illness. Overall, 61% (343/561) of all the household members had acute infectious illness during KD cases' acute stage, and 92% (130/142) of the families had clusters of infectious illness. CONCLUSION: A total of 66% KD cases had positive contact with ill household members prior to their disease onset and 92% of families had clusters of infectious illness, so KD is strongly associated with infections.
BACKGROUND/ PURPOSE:Kawasaki disease (KD) is a disease of unknown cause and the causative agent is most likely to be infectious in nature. To investigate the household transmission pattern of infectious illness and etiology, we thus initiated a prospective case and household study. METHODS: We enrolled KD cases and their household members from February 2004 to September 2008. The KD cases and their household members accepted questionnaire-based interviews of the contact history, signs of infection, and symptoms to check whether clusters of infectious illness occurred. RESULTS: A total of 142 KD cases and 561 household members were enrolled. Among the 142 KD cases, 136 cases (96%) were typical KD, and six (4%) were atypical KD. Of the 561 household members, 17% were siblings, 46% were parents, 18% were grandparents, and the others were cousins or babysitters. Prior to the onset of their KD illness, 66% (94/142) KD cases had contact with ill household members. On the same day of the onset of KD cases' illness, 4% (6/142) KD cases had household members with illness. After KD cases' disease onset, 70% (100/142) KD cases had at least one other family member with illness. Overall, 61% (343/561) of all the household members had acute infectious illness during KD cases' acute stage, and 92% (130/142) of the families had clusters of infectious illness. CONCLUSION: A total of 66% KD cases had positive contact with ill household members prior to their disease onset and 92% of families had clusters of infectious illness, so KD is strongly associated with infections.
Authors: Cedric Manlhiot; Brigitte Mueller; Sunita O'Shea; Haris Majeed; Bailey Bernknopf; Michael Labelle; Katherine V Westcott; Heming Bai; Nita Chahal; Catherine S Birken; Rae S M Yeung; Brian W McCrindle Journal: PLoS One Date: 2018-02-07 Impact factor: 3.240
Authors: James B Thissen; Mariko Isshiki; Crystal Jaing; Yoshiro Nagao; Dayanara Lebron Aldea; Jonathan E Allen; Masafumi Izui; Thomas R Slezak; Takafumi Ishida; Tetsuya Sano Journal: PLoS One Date: 2018-12-28 Impact factor: 3.240