Zhi-De Hu1, Yi Sun2, Jie Guo2, Yuan-Lan Huang3, Bao-Dong Qin4, Qian Gao2, Qin Qin2, An-Mei Deng5, Ren-Qian Zhong6. 1. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, PR China; Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, PR China. 2. Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China. 3. Department of Laboratory Medicine, CPLA No. 455 Hospital, Shanghai, PR China. 4. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, PR China. 5. Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China. Electronic address: amdeng70@163.com. 6. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, PR China. Electronic address: 13901628473@163.com.
Abstract
OBJECTIVE: The red blood cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) are increased in various inflammation related diseases, but their clinical significance in primary Sjögren's syndrome (pSS) has not been reported. The aim of the present study was to investigate the clinical significance of RDW and NLR in pSS patients. METHODS: The medical records of pSS patients who were admitted to Changhai Hospital of the Second Military Medical University between April 2012 and December 2013 were retrospectively reviewed. Correlations between RDW, NLR and the patient clinical characteristics were analyzed using the Spearman approach and the multiple linear regression model. RESULTS: Fifty-two pSS patients and 58 healthy controls were enrolled. RDW and NLR were increased in pSS patients and positively correlated with the Sjögren's syndrome disease activity index (SSDAI). CONCLUSION: RDW and NLR may prove to be useful indices to estimate pSS disease activity.
OBJECTIVE: The red blood cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) are increased in various inflammation related diseases, but their clinical significance in primary Sjögren's syndrome (pSS) has not been reported. The aim of the present study was to investigate the clinical significance of RDW and NLR in pSSpatients. METHODS: The medical records of pSSpatients who were admitted to Changhai Hospital of the Second Military Medical University between April 2012 and December 2013 were retrospectively reviewed. Correlations between RDW, NLR and the patient clinical characteristics were analyzed using the Spearman approach and the multiple linear regression model. RESULTS: Fifty-two pSSpatients and 58 healthy controls were enrolled. RDW and NLR were increased in pSSpatients and positively correlated with the Sjögren's syndrome disease activity index (SSDAI). CONCLUSION: RDW and NLR may prove to be useful indices to estimate pSS disease activity.
Authors: O Zengin; M E Onder; A Kalem; M Bilici; I H Türkbeyler; Z A Ozturk; B Kisacik; A M Onat Journal: Z Rheumatol Date: 2018-03 Impact factor: 1.372