Literature DB >> 25204815

Continuous synthesis of artemisinin-derived medicines.

Kerry Gilmore1, Daniel Kopetzki, Ju Weon Lee, Zoltán Horváth, D Tyler McQuade, Andreas Seidel-Morgenstern, Peter H Seeberger.   

Abstract

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

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Year:  2014        PMID： 25204815     DOI： 10.1039/c4cc05098c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

Review 1.  The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2015-07-17       Impact factor: 2.883

2.  Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography.

Authors:  Róbert Örkényi; János Éles; Ferenc Faigl; Péter Vincze; Anita Prechl; Zoltán Szakács; János Kóti; István Greiner
Journal:  Angew Chem Int Ed Engl       Date:  2017-06-19       Impact factor: 15.336

3.  Stereoelectronic source of the anomalous stability of bis-peroxides.

Authors:  Gabriel Dos Passos Gomes; Vera Vil'; Alexander Terent'ev; Igor V Alabugin
Journal:  Chem Sci       Date:  2015-09-07       Impact factor: 9.825

Review 4.  Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic.

Authors:  Chinmay A Shukla; Amol A Kulkarni
Journal:  Beilstein J Org Chem       Date:  2017-05-19       Impact factor: 2.883

5.  A simplified and scalable synthesis of artesunate.

Authors:  Armin Presser; Andrea Feichtinger; Silke Buzzi
Journal:  Monatsh Chem       Date:  2016-12-02       Impact factor: 1.451

6.  Practical and economic lithiations of functionalized arenes and heteroarenes using Cy2NLi in the presence of Mg, Zn or La halides in a continuous flow.

Authors:  Matthias R Becker; Maximilian A Ganiek; Paul Knochel
Journal:  Chem Sci       Date:  2015-08-10       Impact factor: 9.825

7.  Concise synthesis of artemisinin from a farnesyl diphosphate analogue.

Authors:  Xiaoping Tang; Melodi Demiray; Thomas Wirth; Rudolf K Allemann
Journal:  Bioorg Med Chem       Date:  2017-04-04       Impact factor: 3.641

8.  Synthetic Approaches to Mono- and Bicyclic Perortho-Esters with a Central 1,2,4-Trioxane Ring as the Privileged Lead Structure in Antimalarial and Antitumor-Active Peroxides and Clarification of the Peroxide Relevance.

Authors:  Axel G Griesbeck; Maria Bräutigam; Margarethe Kleczka; Angela Raabe
Journal:  Molecules       Date:  2017-01-11       Impact factor: 4.411

9.  Optimising Terpene Synthesis with Flow Biocatalysis.

Authors:  Xiaoping Tang; Rudolf K Allemann; Thomas Wirth
Journal:  European J Org Chem       Date:  2017-01-13

10.  In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols.

Authors:  Peter J Cossar; Jennifer R Baker; Nicholas Cain; Adam McCluskey
Journal:  R Soc Open Sci       Date:  2018-04-04       Impact factor: 2.963
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