Lindsay Reder1, Emanuel Della-Torre2, John H Stone3, Matthew Mori4, Phillip Song5. 1. Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, California, USA. 2. Università Vita-Salute San Raffaele, Unit of Medicine and Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy Harvard Medical School, Boston, Massachusetts, USA. 3. Harvard Medical School, Boston, Massachusetts, USA Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA. 4. Harvard Medical School, Boston, Massachusetts, USA Division of Laryngology and Center for Neurolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. 5. Harvard Medical School, Boston, Massachusetts, USA Division of Laryngology and Center for Neurolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA phillip_song@meei.harvard.edu.
Abstract
OBJECTIVE: The objective of this report is to characterize IgG4-related disease (IgG4-RD) as it is manifested in the head and neck and describe a series of patients with a rarely described presentation in laryngopharyngeal subsites. METHODS: Here, we illustrate the presentation and clinical course of 3 patients with laryngopharyngeal manifestations of IgG4-RD, including the manner of diagnosis and effective treatment. RESULTS: Three patients with laryngopharyngeal lesions were ultimately diagnosed with IgG4-RD after lengthy work-up. The diagnostic criteria and treatment protocols are explained. CONCLUSION: IgG4-related disease is a fibroinflammatory disorder now described in almost every organ system. The head and neck regions are among the most common areas of involvement, however, reports of laryngopharyngeal involvement are rare. We also summarize current knowledge of this entity and discuss established diagnostic criteria and clinical findings.
OBJECTIVE: The objective of this report is to characterize IgG4-related disease (IgG4-RD) as it is manifested in the head and neck and describe a series of patients with a rarely described presentation in laryngopharyngeal subsites. METHODS: Here, we illustrate the presentation and clinical course of 3 patients with laryngopharyngeal manifestations of IgG4-RD, including the manner of diagnosis and effective treatment. RESULTS: Three patients with laryngopharyngeal lesions were ultimately diagnosed with IgG4-RD after lengthy work-up. The diagnostic criteria and treatment protocols are explained. CONCLUSION: IgG4-related disease is a fibroinflammatory disorder now described in almost every organ system. The head and neck regions are among the most common areas of involvement, however, reports of laryngopharyngeal involvement are rare. We also summarize current knowledge of this entity and discuss established diagnostic criteria and clinical findings.
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