Nicolas Cherbuin1, Kerry Sargent-Cox2, Simon Easteal3, Perminder Sachdev4, Kaarin J Anstey2. 1. Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia. Electronic address: nicolas.cherbuin@anu.edu.au. 2. Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia. 3. John Curtin School of Medical Research, Australian National University, Canberra, Australia. 4. School of Psychiatry, University of New South Wales, Sydney, Australia.
Abstract
OBJECTIVE: To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy. METHODS: Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60-64 years free from dementia, mild cognitive impairment, and other neurological disorders. RESULTS: SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology. CONCLUSION:Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries.
RCT Entities:
OBJECTIVE: To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy. METHODS: Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60-64 years free from dementia, mild cognitive impairment, and other neurological disorders. RESULTS:SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology. CONCLUSION:Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries.
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