| Literature DB >> 25204496 |
Yuhai Zhao1, Surjyadipta Bhattacharjee, Brandon M Jones, James M Hill, Christian Clement, Kumar Sambamurti, Prerna Dua, Walter J Lukiw.
Abstract
Amyloid is a generic term for insoluble, often intensely hydrophobic, fibrous protein aggregates that arise from inappropriately folded versions of naturally-occurring polypeptides. The abnormal generation and accumulation of amyloid, often referred to as amyloidogenesis, has been associated with the immune and pro-inflammatory pathology of several progressive age-related diseases of the human central nervous system (CNS) including Alzheimer's disease (AD) and age-related macular degeneration (AMD). This 'research perspective' paper reviews some of the research history, biophysics, molecular-genetics and environmental factors concerning the contribution of amyloid beta (Aβ) peptides, derived from beta-amyloid precursor protein (βAPP), to AD and AMD that suggests an extensive similarity in immune and inflammatory degenerative mechanisms between these two CNS diseases.Entities:
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Year: 2014 PMID： 25204496 PMCID： PMC4362880 DOI： 10.1007/s12035-014-8886-3
Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590