| Literature DB >> 25203324 |
Jianning Tao1, Ming-Ming Jiang1, Lichun Jiang2, Jason S Salvo2, Huan-Chang Zeng3, Brian Dawson1, Terry K Bertin1, Pulivarthi H Rao4, Rui Chen2, Lawrence A Donehower5, Francis Gannon6, Brendan H Lee7.
Abstract
Osteogenic sarcoma (OS) is a deadly skeletal malignancy whose cause is unknown. We report here a mouse model of OS based on conditional expression of the intracellular domain of Notch1 (NICD). Expression of the NICD in immature osteoblasts was sufficient to drive the formation of bone tumors, including OS, with complete penetrance. These tumors display features of human OS; namely, histopathology, cytogenetic complexity, and metastatic potential. We show that Notch activation combined with loss of p53 synergistically accelerates OS development in mice, although p53-driven OS is not Rbpj dependent, which demonstrates a dual dominance of the Notch oncogene and p53 mutation in the development of OS. Using this model, we also reveal the osteoblasts as the potential sources of OS.Entities:
Mesh：
Substances：
Year: 2014 PMID： 25203324 PMCID： PMC4159617 DOI： 10.1016/j.ccr.2014.07.023
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743