Robyn T Domsic1. 1. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Abstract
PURPOSE OF REVIEW: To discuss recent advances in serologic testing for systemic sclerosis (SSc)-associated antibodies with respect to the diagnosis and prognosis of the disease. RECENT FINDINGS: The importance of SSc antibodies for diagnosis has become increasingly recognized, as evidenced by incorporation into the 2013 American College of Rheumatology/the European League Against Rheumatism clinical classification criteria for SSc. Two new SSc-associated antibodies and their clinical associations have been described. Multiple cohort studies have reported variable antibody frequency distribution based on geography, but the clinical associations remain much the same. New associations include anti-RNA polymerase III antibodies with gastric antral vascular ectasia, and a temporal association between SSc onset and RNA polymerase III antibodies. SUMMARY: The role and associations of SSc-associated antibodies for diagnosis and internal organ involvement are becoming increasingly accepted.
PURPOSE OF REVIEW: To discuss recent advances in serologic testing for systemic sclerosis (SSc)-associated antibodies with respect to the diagnosis and prognosis of the disease. RECENT FINDINGS: The importance of SSc antibodies for diagnosis has become increasingly recognized, as evidenced by incorporation into the 2013 American College of Rheumatology/the European League Against Rheumatism clinical classification criteria for SSc. Two new SSc-associated antibodies and their clinical associations have been described. Multiple cohort studies have reported variable antibody frequency distribution based on geography, but the clinical associations remain much the same. New associations include anti-RNA polymerase III antibodies with gastric antral vascular ectasia, and a temporal association between SSc onset and RNA polymerase III antibodies. SUMMARY: The role and associations of SSc-associated antibodies for diagnosis and internal organ involvement are becoming increasingly accepted.
Authors: Tatiana S Rodriguez-Reyna; Andrea Hinojosa-Azaola; Cynthia Martinez-Reyes; Carlos A Nuñez-Alvarez; Rocío Torrico-Lavayen; José Luis García-Hernández; Javier Cabiedes-Contreras Journal: Autoimmunity Date: 2011-08-30 Impact factor: 2.815
Authors: Robert W Koschik; Noreen Fertig; Mary R Lucas; Robyn T Domsic; Thomas A Medsger Journal: Clin Exp Rheumatol Date: 2012-05-29 Impact factor: 4.473
Authors: Frank van den Hoogen; Dinesh Khanna; Jaap Fransen; Sindhu R Johnson; Murray Baron; Alan Tyndall; Marco Matucci-Cerinic; Raymond P Naden; Thomas A Medsger; Patricia E Carreira; Gabriela Riemekasten; Philip J Clements; Christopher P Denton; Oliver Distler; Yannick Allanore; Daniel E Furst; Armando Gabrielli; Maureen D Mayes; Jacob M van Laar; James R Seibold; Laszlo Czirjak; Virginia D Steen; Murat Inanc; Otylia Kowal-Bielecka; Ulf Müller-Ladner; Gabriele Valentini; Douglas J Veale; Madelon C Vonk; Ulrich A Walker; Lorinda Chung; David H Collier; Mary Ellen Csuka; Barri J Fessler; Serena Guiducci; Ariane Herrick; Vivien M Hsu; Sergio Jimenez; Bashar Kahaleh; Peter A Merkel; Stanislav Sierakowski; Richard M Silver; Robert W Simms; John Varga; Janet E Pope Journal: Ann Rheum Dis Date: 2013-11 Impact factor: 19.103
Authors: Marie Vanthuyne; Vanessa Smith; Ellen De Langhe; Jens Van Praet; Seher Arat; Geneviève Depresseux; Rene Westhovens; Daniel Blockmans; Valérie Badot; Elie Cogan; Filip De Keyser; Frédéric A Houssiau Journal: J Rheumatol Date: 2012-09-15 Impact factor: 4.666
Authors: Florian M P Meier; Klaus W Frommer; Robert Dinser; Ulrich A Walker; Laszlo Czirjak; Christopher P Denton; Yannick Allanore; Oliver Distler; Gabriela Riemekasten; Gabriele Valentini; Ulf Müller-Ladner Journal: Ann Rheum Dis Date: 2012-05-21 Impact factor: 19.103
Authors: Rudolf Mierau; Pia Moinzadeh; Gabriela Riemekasten; Inga Melchers; Michael Meurer; Frank Reichenberger; Michael Buslau; Margitta Worm; Norbert Blank; Rüdiger Hein; Ulf Müller-Ladner; Annegret Kuhn; Cord Sunderkötter; Aaron Juche; Christiane Pfeiffer; Christoph Fiehn; Michael Sticherling; Percy Lehmann; Rudolf Stadler; Eckhard Schulze-Lohoff; Cornelia Seitz; Ivan Foeldvari; Thomas Krieg; Ekkehard Genth; Nicolas Hunzelmann Journal: Arthritis Res Ther Date: 2011-10-21 Impact factor: 5.156
Authors: Zsuzsanna H McMahan; Tricia R Cottrell; Fredrick M Wigley; Brendan Antiochos; Elias T Zambidis; Tea Soon Park; Marc K Halushka; Laura Gutierrez-Alamillo; Raffaello Cimbro; Antony Rosen; Livia Casciola-Rosen Journal: Arthritis Rheumatol Date: 2016-10 Impact factor: 10.995