Alexios Matikas1, George Kanellis2, Christos Papadimitriou3, Theodora Papadaki2, Athanasios Kotsakis1, Meletios A Dimopoulos3, Vassilis Georgoulias4. 1. Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Greece. 2. Department of Hematopathology, "Evangelismos" Hosptial, Athens, Greece. 3. Bone Marrow Transplantation Unit, Department of Clinical Therapeutics, "Alexandra" Hospital, Athens, Greece. 4. Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Greece georgsec@med.uoc.gr.
Abstract
BACKGROUND: Plasmablastic lymphoma (PBL) is a rare entity which is often causally related to infection by the Human Immunodeficiency Virus (HIV). Despite its predilection for oral cavity involvement, multiple cases of extra-oral involvement have been reported in the literature, more often among immunocompetent individuals. CASE REPORT: Herein we present the first case of primary PBL of the breast in an otherwise immunocompetent 36-year-old woman who was successfully treated with consolidation megatherapy and autologous stem cell transplantation. CONCLUSION: PBL carries a particularly poor prognosis and more intensive treatment is usually warranted. However, no treatment guidelines exist and treatment choices are made based on case reports and small retrospective case series. Copyright
BACKGROUND: Plasmablastic lymphoma (PBL) is a rare entity which is often causally related to infection by the Human Immunodeficiency Virus (HIV). Despite its predilection for oral cavity involvement, multiple cases of extra-oral involvement have been reported in the literature, more often among immunocompetent individuals. CASE REPORT: Herein we present the first case of primary PBL of the breast in an otherwise immunocompetent 36-year-old woman who was successfully treated with consolidation megatherapy and autologous stem cell transplantation. CONCLUSION: PBL carries a particularly poor prognosis and more intensive treatment is usually warranted. However, no treatment guidelines exist and treatment choices are made based on case reports and small retrospective case series. Copyright