Ari Ylikoski1, Kirsti Martikainen2, Markku Partinen3. 1. Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland; Hospital of Laakso, Department of Neurology, Helsinki, Finland. Electronic address: ari.ylikoski@fimnet.fi. 2. The Finnish Parkinson Association, The Finnish Parkinson Foundation, Turku, Finland. 3. Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland; Institute of Clinical Medicine, Department of Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
Abstract
BACKGROUND: Sleep disorders are among the most common non-motor symptoms in Parkinson's disease. METHOD: The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinson patients, aged 43 to 89 years. The response rate was 59.0% and of these 77% had answered to all questions that were used in the analyses (N = 661). RESULTS: The prevalence of REM sleep behavior disorder (RBD) evaluated by the RBDSQ ≥ 6 was 39.0%. The occurrences of other parasomnias (≥ 1/week) in patients with PD were: nightmares 17.2%, night terrors 3.9%, sleepwalking 1.8%, enuresis 21.0%, and hallucinations 15.3%. Occurrences (≥ 1/week) of the isolated sleep symptoms were: nocturnal sweating 28.8%, bruxism 4.7%, and sleep talking 21.7%. Association of RBD with sleepwalking (parasomnia overlap disorder) was found in 1.7% of all PD patients. Adjusted logistic regression analysis showed that weekly nightmares (OR 12.5; 95% CI 5.3 to 29.7), hallucinations (OR 5.1; 2.1 to 12.4), sleep talking (OR 11.6; 5.9 to 22.8), male gender (OR 1.9; 1.1 to 3.1), and restless legs syndrome (OR 4.7; 1.7 to 13.2) associated with the presence of RBD. CONCLUSION: Parkinson patients with RBD have often also other parasomnias and/or isolated sleep symptoms.
BACKGROUND:Sleep disorders are among the most common non-motor symptoms in Parkinson's disease. METHOD: The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinsonpatients, aged 43 to 89 years. The response rate was 59.0% and of these 77% had answered to all questions that were used in the analyses (N = 661). RESULTS: The prevalence of REM sleep behavior disorder (RBD) evaluated by the RBDSQ ≥ 6 was 39.0%. The occurrences of other parasomnias (≥ 1/week) in patients with PD were: nightmares 17.2%, night terrors 3.9%, sleepwalking 1.8%, enuresis 21.0%, and hallucinations 15.3%. Occurrences (≥ 1/week) of the isolated sleep symptoms were: nocturnal sweating 28.8%, bruxism 4.7%, and sleep talking 21.7%. Association of RBD with sleepwalking (parasomnia overlap disorder) was found in 1.7% of all PDpatients. Adjusted logistic regression analysis showed that weekly nightmares (OR 12.5; 95% CI 5.3 to 29.7), hallucinations (OR 5.1; 2.1 to 12.4), sleep talking (OR 11.6; 5.9 to 22.8), male gender (OR 1.9; 1.1 to 3.1), and restless legs syndrome (OR 4.7; 1.7 to 13.2) associated with the presence of RBD. CONCLUSION:Parkinsonpatients with RBD have often also other parasomnias and/or isolated sleep symptoms.
Authors: Soufiane Boucetta; Ali Salimi; Mahsa Dadar; Barbara E Jones; D Louis Collins; Thien Thanh Dang-Vu Journal: Sci Rep Date: 2016-06-01 Impact factor: 4.379