Shajith Anoop1, Anoop Misra2, Swati Bhardwaj1, Seema Gulati1. 1. Center of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi. 2. Center of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi; Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, Nehru place, New Delhi; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India. Electronic address: anoopmisra@metabolicresearchindia.com.
Abstract
AIM: To investigate the associations of high body fat and low muscle mass with arterial stiffness in Asian Indians with type 2 diabetes mellitus (T2DM) in North India. METHODS: In this cross sectional study, subjects with T2DM (males n=110, females n=58, mean age: 53.8±10.0years) were recruited. Anthropometry and body composition analysis were performed and measures of glycemia, lipids and PWV were analyzed. RESULTS: Significant positive correlation was observed between PWV and body fat (p<0.05), left leg fat (p<0.05), and right leg fat (p<0.01) percentages only in females. In males, significant negative correlation was observed between PWV and truncal fat free mass (p<0.05) and fat free mass in right arm (p=0.05) and left arm (p<0.05). In both males and females, significant negative correlation was observed between PWV and fat free mass in left leg (p<0.01) and for right leg fat free mass only in females. CONCLUSION: Excess adiposity and low fat free mass are associated with arterial stiffening in Asian Indians with T2DM in North India, with significant gender differences.
AIM: To investigate the associations of high body fat and low muscle mass with arterial stiffness in Asian Indians with type 2 diabetes mellitus (T2DM) in North India. METHODS: In this cross sectional study, subjects with T2DM (males n=110, females n=58, mean age: 53.8±10.0years) were recruited. Anthropometry and body composition analysis were performed and measures of glycemia, lipids and PWV were analyzed. RESULTS: Significant positive correlation was observed between PWV and body fat (p<0.05), left leg fat (p<0.05), and right leg fat (p<0.01) percentages only in females. In males, significant negative correlation was observed between PWV and truncal fat free mass (p<0.05) and fat free mass in right arm (p=0.05) and left arm (p<0.05). In both males and females, significant negative correlation was observed between PWV and fat free mass in left leg (p<0.01) and for right leg fat free mass only in females. CONCLUSION: Excess adiposity and low fat free mass are associated with arterial stiffening in Asian Indians with T2DM in North India, with significant gender differences.
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