BACKGROUND: Basal cell carcinoma (BCC) recurrences, especially in the facial region, represent a complex cosmetic problem. To date the possibility of predicting recurrence is supported solely by the histologic subtype. OBJECTIVE: To evaluate the relationship between BCC histologic subtypes linked to high and low risk of recurrence and the presence of hyperechoic spots on sonography. METHODS: Retrospective analysis of the pre-surgical ultrasound examinations of primary BCC tumours with visualization and counting of intra-tumoural hyperechoic spots. The data were then correlated with the corresponding histologic subtype. RESULTS: Thirty one patients with histologically proven BCC were included in the study. Hyperechoic spots were detected in all cases and there was a positive, statistically significant association between hyperechoic spots count and high recurrence risk histologic subtypes. Higher hyperechoic spots count was found in the recurrence-prone micronodular, sclerosing variant and morpheiform BCC subtypes. Low risk and high risk of recurrence showed a significant difference on the mean hyperechoic spots count of 5.5 (range: 3-25) and 8 (4-81). A cut-off point ≥7 hyperechoic spots presented a sensitivity of 79% and specificity of 53% for predicting the high risk of recurrence subtypes. CONCLUSION: The presence and count of hyperechoic spots within BCC lesions may help predicting the high risk of recurrence histologic subtypes.
BACKGROUND:Basal cell carcinoma (BCC) recurrences, especially in the facial region, represent a complex cosmetic problem. To date the possibility of predicting recurrence is supported solely by the histologic subtype. OBJECTIVE: To evaluate the relationship between BCC histologic subtypes linked to high and low risk of recurrence and the presence of hyperechoic spots on sonography. METHODS: Retrospective analysis of the pre-surgical ultrasound examinations of primary BCC tumours with visualization and counting of intra-tumoural hyperechoic spots. The data were then correlated with the corresponding histologic subtype. RESULTS: Thirty one patients with histologically proven BCC were included in the study. Hyperechoic spots were detected in all cases and there was a positive, statistically significant association between hyperechoic spots count and high recurrence risk histologic subtypes. Higher hyperechoic spots count was found in the recurrence-prone micronodular, sclerosing variant and morpheiform BCC subtypes. Low risk and high risk of recurrence showed a significant difference on the mean hyperechoic spots count of 5.5 (range: 3-25) and 8 (4-81). A cut-off point ≥7 hyperechoic spots presented a sensitivity of 79% and specificity of 53% for predicting the high risk of recurrence subtypes. CONCLUSION: The presence and count of hyperechoic spots within BCC lesions may help predicting the high risk of recurrence histologic subtypes.
Authors: Cristian Navarrete-Dechent; Konstantinos Liopyris; Ayelet Rishpon; Nadeem G Marghoob; Miguel Cordova; Stephen W Dusza; Aditi Sahu; Kivanc Kose; Margaret Oliviero; Harold Rabinovitz; Klaus J Busam; Michael A Marchetti; Chih-Chan J Chen; Ashfaq A Marghoob Journal: JAMA Dermatol Date: 2020-08-01 Impact factor: 10.282
Authors: Orlando Catalano; Fernando Alfageme Roldán; Carlo Varelli; Robert Bard; Antonio Corvino; Ximena Wortsman Journal: J Ultrasound Date: 2019-05-08
Authors: Cristian Navarrete-Dechent; Miguel Cordova; Konstantinos Liopyris; Saud Aleissa; Milind Rajadhyaksha; Gil'ad Cohen; Ashfaq A Marghoob; Anthony M Rossi; Christopher A Barker Journal: J Am Acad Dermatol Date: 2020-08-20 Impact factor: 15.487
Authors: Raluca Maria Bungărdean; Mircea Sebastian Şerbănescu; Horaţiu Alexandru Colosi; Maria Crişan Journal: Rom J Morphol Embryol Date: 2021 Apr-Jun Impact factor: 1.033