Literature DB >> 25199495

Novel treatment for recalcitrant rectovaginal fistulas: fat injection.

L de Weerd1, S Weum, S Norderval.   

Abstract

INTRODUCTION AND HYPOTHESIS: The treatment of recurrent rectovaginal fistula (RVF) is a challenge for the surgeon. Within plastic surgery fat harvesting and subsequent transplantation by injection is an established method for soft tissue augmentation. We hypothesized whether soft tissue augmentation by transperineal injection of autologous fat could stimulate fistula healing in women with recalcitrant RVF.
MATERIALS AND METHODS: Six patients with a recalcitrant RVF, 4 due to obstetric injury and 2 associated with Crohn's disease, were included in the pilot study. The fat graft from the lower abdomen was injected transperineally around the fistula tract. At the end of the injection procedure the fistula tract was transected transversely.
RESULTS: In 1 patient the fistula healed after a single treatment, while the other 5 required two treatments with a 6-week interval. In the patients with an RVF due to obstetric injury no recurrence occurred during follow-up, mean 41 months (range 4-53). In the 2 patients with Crohn's disease a new fistula developed after 23 and 25 months respectively.
CONCLUSION: We describe fat injection as a new and promising method for the treatment of a recalcitrant RVF where previous attempts had failed to heal the fistula. This method does not include wide dissection, thereby reducing the risk of injury to important neurovascular structures. The method is minimally invasive and causes minimal donor site morbidity. More advanced techniques can still be used in cases of recurrence.

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Year:  2014        PMID: 25199495     DOI: 10.1007/s00192-014-2497-4

Source DB:  PubMed          Journal:  Int Urogynecol J        ISSN: 0937-3462            Impact factor:   2.894


  26 in total

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Review 2.  Basic science review on adipose tissue for clinicians.

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3.  Low harvest pressure enhances autologous fat graft viability.

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Review 4.  Surgical approaches to postobstetrical perineal body defects (rectovaginal fistula and chronic third and fourth-degree lacerations).

Authors:  John O L Delancey; Norman F Miller; Mitchell B Berger
Journal:  Clin Obstet Gynecol       Date:  2010-03       Impact factor: 2.190

5.  Repair of simple rectovaginal fistulas. Influence of previous repairs.

Authors:  A C Lowry; A G Thorson; D A Rothenberger; S M Goldberg
Journal:  Dis Colon Rectum       Date:  1988-09       Impact factor: 4.585

6.  Interposition of vital bulbocavernosus graft in the treatment of both simple and recurrent rectovaginal fistulas.

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7.  Social and economic consequences of obstetric fistula: life changed forever?

Authors:  S Ahmed; S A Holtz
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8.  Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.

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Review 9.  Anal sphincter integrity and function influences outcome in rectovaginal fistula repair.

Authors:  C B Tsang; R D Madoff; W D Wong; D A Rothenberger; C O Finne; D Singer; A C Lowry
Journal:  Dis Colon Rectum       Date:  1998-09       Impact factor: 4.585

Review 10.  Rectovaginal fistula in Crohn's disease.

Authors:  S M Andreani; H H Dang; P Grondona; A Z Khan; D P Edwards
Journal:  Dis Colon Rectum       Date:  2007-09-11       Impact factor: 4.585

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  3 in total

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Authors:  S Norderval; L Lundby; H Hougaard; S Buntzen; S Weum; L de Weerd
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2.  Evaluation and management of perianal abscess and anal fistula: SICCR position statement.

Authors:  A Amato; C Bottini; P De Nardi; P Giamundo; A Lauretta; A Realis Luc; V Piloni
Journal:  Tech Coloproctol       Date:  2020-01-23       Impact factor: 3.781

3.  Molecular differences of adipose-derived mesenchymal stem cells between non-responders and responders in treatment of  transphincteric perianal fistulas.

Authors:  Michaela Tencerova; Lilli Lundby; Steen Buntzen; Stig Norderval; Helene Tarri Hougaard; Bodil Ginnerup Pedersen; Moustapha Kassem
Journal:  Stem Cell Res Ther       Date:  2021-11-24       Impact factor: 6.832

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