OBJECTIVE: To explore serum redox status differences among different types of dyslipidemia patients. METHOD: One hundred and nineteen healthy people and two hundred and ninety four dyslipidemic participants on clinical examination were divided into six groups: control group, hypercholesterolemia (HTC), hypertriglyceridemia (HTG), combined hyperlipidemia (CH), low level of high-density lipoprotein cholesterol (LHDL) and hyperlipidemia with LHDL (HBL + LHDL) according to blood lipid profiles. Malonaldehyde (MDA), total antioxidant capacity (T-AOC), advanced oxidation protein products (AOPP) and dityrosine (DT) in serum were measured. RESULTS: In all participants, the T-AOC, AOPP and DT levels in HTG, CH and HBL + LHDL groups were significantly (P < 0.05) higher than that in controls, further, LHDL with or without hyperlipidemia had elevated (P < 0.05) MDA level compared with control, HTC and HTG groups, whereas levels of AOPP and DT in LHDL were not different with controls. Triglycerides values showed a positive correlation with MDA, T-AOC, AOPP and DT. CONCLUSION: Level of serum oxidative stress was higher in hyperlipidemia patients than in healthy people, and high triglycerides levels were more likely to cause an imbalance in redox status.
OBJECTIVE: To explore serum redox status differences among different types of dyslipidemiapatients. METHOD: One hundred and nineteen healthy people and two hundred and ninety four dyslipidemic participants on clinical examination were divided into six groups: control group, hypercholesterolemia (HTC), hypertriglyceridemia (HTG), combined hyperlipidemia (CH), low level of high-density lipoprotein cholesterol (LHDL) and hyperlipidemia with LHDL (HBL + LHDL) according to blood lipid profiles. Malonaldehyde (MDA), total antioxidant capacity (T-AOC), advanced oxidation protein products (AOPP) and dityrosine (DT) in serum were measured. RESULTS: In all participants, the T-AOC, AOPP and DT levels in HTG, CH and HBL + LHDL groups were significantly (P < 0.05) higher than that in controls, further, LHDL with or without hyperlipidemia had elevated (P < 0.05) MDA level compared with control, HTC and HTG groups, whereas levels of AOPP and DT in LHDL were not different with controls. Triglycerides values showed a positive correlation with MDA, T-AOC, AOPP and DT. CONCLUSION: Level of serum oxidative stress was higher in hyperlipidemiapatients than in healthy people, and high triglycerides levels were more likely to cause an imbalance in redox status.
Authors: Grazielle V B Huguenin; Glaucia M M Oliveira; Annie S B Moreira; Tatiana D Saint'Pierre; Rodrigo A Gonçalves; Alessandra R Pinheiro-Mulder; Anderson J Teodoro; Ronir R Luiz; Glorimar Rosa Journal: Nutr J Date: 2015-05-29 Impact factor: 3.271