Devesh Thakkar1, Anirudh V Deshpande2, Sean E Kennedy3. 1. School of Women's and Children's Health, Medicine UNSW, University of New South Wales, Sydney, New South Wales, Australia. 2. 1] Urology, Sydney Children's Hospital Network, Sydney, New South Wales, Australia [2] Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, New South Wales, Australia. 3. 1] School of Women's and Children's Health, Medicine UNSW, University of New South Wales, Sydney, New South Wales, Australia [2] Nephrology, Sydney Children's Hospital, Randwick, New South Wales, Australia [3] Australian Centre for Perinatal Science, University of New South Wales, Sydney, New South Wales, Australia.
Abstract
BACKGROUND: Posterior urethral valves (PUV) are a common cause of chronic kidney disease in young children, yet there is a paucity of knowledge about etiology and incidence. We sought to determine the incidence in Australia and to explore whether any demographic features were associated with incidence. METHODS: PUV cases born between 2004 and 2009 in New South Wales (NSW) were identified by linkage analysis of two registries. The incidence rate was compared to registries from two other states. An audit was then performed at two pediatric centers. RESULTS: Seventy-one boys were born and diagnosed in NSW with PUV, giving a live-birth incidence of 1.28 per 10,000. Fifty-one cases were treated at the two participating centers. Fifty-three percent of these were suspected on antenatal ultrasound. Of the remaining cases, 45% were detected in the neonatal period, with 50% of all postnatal cases presenting with urinary tract infection. No association was observed between maternal factors or socioeconomic status and PUV incidence. CONCLUSION: PUV was found in 1 in 7,800, a similar rate to international studies. Although almost half of cases are antenatally detected, a significant proportion present outside the neonatal period. Birth incidence was not associated with maternal or demographic factors.
BACKGROUND: Posterior urethral valves (PUV) are a common cause of chronic kidney disease in young children, yet there is a paucity of knowledge about etiology and incidence. We sought to determine the incidence in Australia and to explore whether any demographic features were associated with incidence. METHODS: PUV cases born between 2004 and 2009 in New South Wales (NSW) were identified by linkage analysis of two registries. The incidence rate was compared to registries from two other states. An audit was then performed at two pediatric centers. RESULTS: Seventy-one boys were born and diagnosed in NSW with PUV, giving a live-birth incidence of 1.28 per 10,000. Fifty-one cases were treated at the two participating centers. Fifty-three percent of these were suspected on antenatal ultrasound. Of the remaining cases, 45% were detected in the neonatal period, with 50% of all postnatal cases presenting with urinary tract infection. No association was observed between maternal factors or socioeconomic status and PUV incidence. CONCLUSION: PUV was found in 1 in 7,800, a similar rate to international studies. Although almost half of cases are antenatally detected, a significant proportion present outside the neonatal period. Birth incidence was not associated with maternal or demographic factors.
Authors: Joshua Jonathan Norris; Jeffrey Pradeep Raj; Tia Teresa Thomas; Tijo Thomas Maleperambil; Attibele Mahadevaiah Shubha Journal: J Family Med Prim Care Date: 2021-11-05
Authors: Bénédicte Buffin-Meyer; Julie Klein; Loes F M van der Zanden; Elena Levtchenko; Panogiotis Moulos; Nadia Lounis; Françoise Conte-Auriol; An Hindryckx; Elke Wühl; Nicola Persico; Dick Oepkes; Michiel F Schreuder; Marcin Tkaczyk; Gema Ariceta; Magdalena Fossum; Paloma Parvex; Wout Feitz; Henning Olsen; Giovanni Montini; Stéphane Decramer; Joost P Schanstra Journal: Clin Kidney J Date: 2019-09-26