Literature DB >> 25198057

Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents.

Achmad N Hidayatullah1, Erin Wachter, David K Heidary, Sean Parkin, Edith C Glazer.   

Abstract

Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.

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Year:  2014        PMID： 25198057     DOI： 10.1021/ic5017164

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  21 in total

1.  An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy.

Authors:  Jessica K White; Russell H Schmehl; Claudia Turro
Journal:  Inorganica Chim Acta       Date:  2016-06-18       Impact factor: 2.545

2.  Photochemical Properties and Structure-Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents.

Authors:  Dmytro Havrylyuk; David K Heidary; Leona Nease; Sean Parkin; Edith C Glazer
Journal:  Eur J Inorg Chem       Date:  2017-02-15       Impact factor: 2.524

3.  Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands.

Authors:  Lars Kohler; Leona Nease; Pascal Vo; Jenna Garofolo; David K Heidary; Randolph P Thummel; Edith C Glazer
Journal:  Inorg Chem       Date:  2017-09-26       Impact factor: 5.165

4.  Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines.

Authors:  Sierra C Marker; Samantha N MacMillan; Warren R Zipfel; Zhi Li; Peter C Ford; Justin J Wilson
Journal:  Inorg Chem       Date:  2018-01-11       Impact factor: 5.165

Review 5.  The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials.

Authors:  Leli Zeng; Pranav Gupta; Yanglu Chen; Enju Wang; Liangnian Ji; Hui Chao; Zhe-Sheng Chen
Journal:  Chem Soc Rev       Date:  2017-10-02       Impact factor: 54.564

6.  Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of "dual action" photoactivated agents.

Authors:  Dmytro Havrylyuk; Megha Deshpande; Sean Parkin; Edith C Glazer
Journal:  Chem Commun (Camb)       Date:  2018-11-01       Impact factor: 6.222

7.  Singlet Oxygen Formation vs Photodissociation for Light-Responsive Protic Ruthenium Anticancer Compounds: The Oxygenated Substituent Determines Which Pathway Dominates.

Authors:  Fengrui Qu; Robert W Lamb; Colin G Cameron; Seungjo Park; Olaitan Oladipupo; Jessica L Gray; Yifei Xu; Houston D Cole; Marco Bonizzoni; Yonghyun Kim; Sherri A McFarland; Charles Edwin Webster; Elizabeth T Papish
Journal:  Inorg Chem       Date:  2021-02-03       Impact factor: 5.165

8.  Fine-Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity†.

Authors:  Houston D Cole; John A Roque; Liubov M Lifshits; Rachel Hodges; Patrick C Barrett; Dmytro Havrylyuk; David Heidary; Elamparuthi Ramasamy; Colin G Cameron; Edith C Glazer; Sherri A McFarland
Journal:  Photochem Photobiol       Date:  2021-03-28       Impact factor: 3.521

Review 9.  Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes.

Authors:  Austin C Hachey; Dmytro Havrylyuk; Edith C Glazer
Journal:  Curr Opin Chem Biol       Date:  2021-03-30       Impact factor: 8.822

10.  Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.

Authors:  Nicholas Toupin; Sean J Steinke; Sandeep Nadella; Ao Li; Thomas N Rohrabaugh; Eric R Samuels; Claudia Turro; Irina F Sevrioukova; Jeremy J Kodanko
Journal:  J Am Chem Soc       Date:  2021-06-10       Impact factor: 16.383
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