Literature DB >> 25198048

Inhibiting Janus kinases to treat alopecia areata.

Sherrie J Divito1, Thomas S Kupper1.   

Abstract

Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ⁺NKG2D⁺ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.

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Year:  2014        PMID： 25198048     DOI： 10.1038/nm.3685

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  15 in total

Review 1.  Alopecia areata.

Authors:  Amos Gilhar; Amos Etzioni; Ralf Paus
Journal:  N Engl J Med       Date:  2012-04-19       Impact factor: 91.245

2.  Alopecia areata induced in C3H/HeJ mice by interferon-gamma: evidence for loss of immune privilege.

Authors:  Amos Gilhar; Yossi Kam; Bedia Assy; Richard S Kalish
Journal:  J Invest Dermatol       Date:  2005-01       Impact factor: 8.551

3.  Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.

Authors:  Lynn Petukhova; Madeleine Duvic; Maria Hordinsky; David Norris; Vera Price; Yutaka Shimomura; Hyunmi Kim; Pallavi Singh; Annette Lee; Wei V Chen; Katja C Meyer; Ralf Paus; Colin A B Jahoda; Christopher I Amos; Peter K Gregersen; Angela M Christiano
Journal:  Nature       Date:  2010-07-01       Impact factor: 49.962

4.  Interferon-gamma-deficient mice are resistant to the development of alopecia areata.

Authors:  P Freyschmidt-Paul; K J McElwee; R Hoffmann; J P Sundberg; M Vitacolonna; S Kissling; M Zöller
Journal:  Br J Dermatol       Date:  2006-09       Impact factor: 9.302

5.  Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.

Authors:  Anna K Andersson; Percy F Sumariwalla; Fiona E McCann; Parisa Amjadi; Chiwen Chang; Kay McNamee; Ditte Tornehave; Claus Haase; Henrik Agersø; Vibeke W Stennicke; David Ahern; Birgitte Ursø; John Trowsdale; Marc Feldmann; Fionula M Brennan
Journal:  Arthritis Rheum       Date:  2011-09

6.  Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

Authors:  Kamran Ghoreschi; Michael I Jesson; Xiong Li; Jamie L Lee; Sarbani Ghosh; Jason W Alsup; James D Warner; Masao Tanaka; Scott M Steward-Tharp; Massimo Gadina; Craig J Thomas; John C Minnerly; Chad E Storer; Timothy P LaBranche; Zaher A Radi; Martin E Dowty; Richard D Head; Debra M Meyer; Nandini Kishore; John J O'Shea
Journal:  J Immunol       Date:  2011-03-07       Impact factor: 5.422

7.  Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.

Authors:  Alfonso Quintás-Cardama; Kris Vaddi; Phillip Liu; Taghi Manshouri; Jun Li; Peggy A Scherle; Eian Caulder; Xiaoming Wen; Yanlong Li; Paul Waeltz; Mark Rupar; Timothy Burn; Yvonne Lo; Jennifer Kelley; Maryanne Covington; Stacey Shepard; James D Rodgers; Patrick Haley; Hagop Kantarjian; Jordan S Fridman; Srdan Verstovsek
Journal:  Blood       Date:  2010-02-03       Impact factor: 22.113

Review 8.  IL-15 is a growth factor and an activator of CD8 memory T cells.

Authors:  Nan-Ping Weng; Kebin Liu; Marta Catalfamo; Yu Li; Pierre A Henkart
Journal:  Ann N Y Acad Sci       Date:  2002-12       Impact factor: 5.691

Review 9.  Comparison of alopecia areata in human and nonhuman mammalian species.

Authors:  K J McElwee; D Boggess; T Olivry; R F Oliver; D Whiting; D J Tobin; J C Bystryn; L E King; J P Sundberg
Journal:  Pathobiology       Date:  1998       Impact factor: 4.342

10.  Alopecia areata in aging C3H/HeJ mice.

Authors:  J P Sundberg; W R Cordy; L E King
Journal:  J Invest Dermatol       Date:  1994-06       Impact factor: 8.551
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  16 in total

Review 1.  The role of lymphocytes in the development and treatment of alopecia areata.

Authors:  Hongwei Guo; Yabin Cheng; Jerry Shapiro; Kevin McElwee
Journal:  Expert Rev Clin Immunol       Date:  2015-09-07       Impact factor: 4.473

Review 2.  Alopecia Areata: a Comprehensive Review of Pathogenesis and Management.

Authors:  Ralph M Trüeb; Maria Fernanda Reis Gavazzoni Dias
Journal:  Clin Rev Allergy Immunol       Date:  2018-02       Impact factor: 8.667

3.  [20-year-old female with suddenly occurring extensive alopecia : Preparation for the medical specialist examination: Part 21].

Authors:  Carla Thomas; Thomas Vogt
Journal:  Hautarzt       Date:  2018-11       Impact factor: 0.751

Review 4.  JAK Inhibitors for Treatment of Alopecia Areata.

Authors:  Eddy H C Wang; Brigitte N Sallee; Christina I Tejeda; Angela M Christiano
Journal:  J Invest Dermatol       Date:  2018-07-26       Impact factor: 8.551

Review 5.  [Janus kinase inhibitors for the treatment of alopecia areata].

Authors:  Inbar Kobal; Yuval Ramot
Journal:  Hautarzt       Date:  2022-04-28       Impact factor: 0.751

6.  The Immunogenetics of Alopecia areata.

Authors:  Fateme Rajabi; Fahimeh Abdollahimajd; Navid Jabalameli; Mansour Nassiri Kashani; Alireza Firooz
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

Review 7.  Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.

Authors:  Cheng Zhou; Xiangqian Li; Chen Wang; Jianzhong Zhang
Journal:  Clin Rev Allergy Immunol       Date:  2021-08-17       Impact factor: 8.667

8.  Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice.

Authors:  Eunjin Lee; Mingyu Kim; You Jeong Lee
Journal:  Front Immunol       Date:  2022-06-15       Impact factor: 8.786

Review 9.  Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.

Authors:  Amos Gilhar; Adam G Schrum; Amos Etzioni; Herman Waldmann; Ralf Paus
Journal:  Autoimmun Rev       Date:  2016-03-10       Impact factor: 9.754

10.  Precision Medicine and the Practice of Trichiatry: Adapting the Concept.

Authors:  Ralph M Trüeb; Vicky M L Jolliffe; Antonia Fellas Régnier; Hudson Dutra Rezende; Sergio Vañó-Galván; Daisy Kopera; Demetrios Ioannides; Maria Fernanda Reis Gavazzoni Dias; Melanie Macpherson; Aida Gadzhigoroeva; Julya Ovcharenko; Won-Soo Lee; Sundaram Murugusundram; Sotaro Kurata; Mimi Chang; Chuchai Tanglertsampan
Journal:  Skin Appendage Disord       Date:  2019-08-20
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