Geoffrey Y Ku1, David H Ilson. 1. Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: Gastric cancer is an uncommon cancer in the United States but is a very common cancer globally and is endemic in East Asia. It is a virulent cancer that presents with metastatic disease in about one half of United States patients. RECENT FINDINGS: In this review article, we discuss palliative chemotherapy options as well as validated preoperative, perioperative and postoperative strategies for locally advanced disease, which include chemotherapy and/or chemoradiation. SUMMARY: In the metastatic setting, there has been incremental improvement in cytotoxic chemotherapy combinations in the past 2 decades. Two targeted agents - trastuzumab and ramucirumab - are now approved. In the locally advanced setting, perioperative chemotherapy or postoperative chemotherapy or chemoradiation improves outcomes relative to surgery alone.
PURPOSE OF REVIEW: Gastric cancer is an uncommon cancer in the United States but is a very common cancer globally and is endemic in East Asia. It is a virulent cancer that presents with metastatic disease in about one half of United States patients. RECENT FINDINGS: In this review article, we discuss palliative chemotherapy options as well as validated preoperative, perioperative and postoperative strategies for locally advanced disease, which include chemotherapy and/or chemoradiation. SUMMARY: In the metastatic setting, there has been incremental improvement in cytotoxic chemotherapy combinations in the past 2 decades. Two targeted agents - trastuzumab and ramucirumab - are now approved. In the locally advanced setting, perioperative chemotherapy or postoperative chemotherapy or chemoradiation improves outcomes relative to surgery alone.
Authors: Geoffrey Y Ku; Yelena Kemel; Steve B Maron; Joanne F Chou; Vignesh Ravichandran; Zarina Shameer; Anna Maio; Elizabeth S Won; David P Kelsen; David H Ilson; Marinela Capanu; Vivian E Strong; Daniela Molena; Smita Sihag; David R Jones; Daniel G Coit; Yaelle Tuvy; Kendall Cowie; David B Solit; Nikolaus Schultz; Jaclyn F Hechtman; Kenneth Offit; Vijai Joseph; Diana Mandelker; Yelena Y Janjigian; Zsofia K Stadler Journal: JAMA Netw Open Date: 2021-07-01