Literature DB >> 25197424

Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature.

Samir M Dalia1, Pedro Horna2, Ling Zhang2.   

Abstract

Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.

Entities:  

Keywords:  Acute promyelocytic leukemia; All trans-retinoic acid (ATRA); PML-RARA; leukemia; tetraploid

Mesh：

Substances：

Year:  2014        PMID： 25197424      PMCID： PMC4152114     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  16 in total

1.  Polyploidy in acute promyelocytic leukemia without the 15:17 translocation.

Authors:  P Matsouka; C Sambani; N Giannakoulas; A Symeonidis; N Zoumbos
Journal:  Haematologica       Date:  2001-12       Impact factor: 9.941

Review 2.  Acute promyelocytic leukemia with tetraploid karyotype: first report in the Western hemisphere and update of previous reports.

Authors:  Pavan Mahendra Ravella; Delong Liu; Kensuke Kojima; James Weisberger; Osamu Miura; Jun Kuyama; Wing Au; Karen Seiter
Journal:  Leuk Res       Date:  2011-02-25       Impact factor: 3.156

3.  Association of cup-like nuclei in blasts with FLT3 and NPM1 mutations in acute myeloid leukemia.

Authors:  Borae G Park; Hyun-Sook Chi; Seongsoo Jang; Chan-Jeoung Park; Dae-Young Kim; Jung-Hee Lee; Je-Hwan Lee; Kyoo-Hyung Lee
Journal:  Ann Hematol       Date:  2012-12-13       Impact factor: 3.673

4.  Characteristics and prognosis analysis of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide as the front-line therapy.

Authors:  Yinjun Lou; Shanshan Suo; Hongyan Tong; Xingnong Ye; Yungui Wang; Zhimei Chen; Wenbin Qian; Haitao Meng; Wenyuan Mai; Jian Huang; Yin Tong; Jie Jin
Journal:  Leuk Res       Date:  2013-08-16       Impact factor: 3.156

5.  Tetraploid acute promyelocytic leukemia with large bizarre blast cell morphology.

Authors:  W Y Au; S K Ma; C C Lam; L C Chan; Y L Kwong
Journal:  Cancer Genet Cytogenet       Date:  1999-11

6.  Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience.

Authors:  Lionel Adès; Agnes Guerci; Emmanuel Raffoux; Miguel Sanz; Patrice Chevallier; Simona Lapusan; Christian Recher; Xavier Thomas; Consuelo Rayon; Sylvie Castaigne; Olivier Tournilhac; Stephane de Botton; Norbert Ifrah; Jean-Yves Cahn; Eric Solary; Claude Gardin; Nathalie Fegeux; Dominique Bordessoule; Augustin Ferrant; Sandrine Meyer-Monard; Norbert Vey; Herve Dombret; Laurent Degos; Sylvie Chevret; Pierre Fenaux
Journal:  Blood       Date:  2009-12-17       Impact factor: 22.113

7.  Hypocellular acute promyelocytic leukemia with a tetraploid clone characterized by two t(15;17).

Authors:  Kensuke Kojima; Michiyoshi Imaoka; Toshiyuki Noguchi; Hiroshi Narumi; Naoyuki Uchida; Ikuya Sakai; Masaki Yasukawa; Shigeru Fujita
Journal:  Cancer Genet Cytogenet       Date:  2003-09

8.  Tetraploid acute promyelocytic leukemia with double t(15;17) and PML/RARA rearrangements detected by fluorescence in situ hybridization analysis.

Authors:  Seung Hwan Oh; Tae Sung Park; Hyung Hoi Kim; Chulhun L Chang; Eun Yup Lee; Han Chul Son; Joo Seop Chung; Goon Jae Cho
Journal:  Cancer Genet Cytogenet       Date:  2003-08

9.  Arsenic trioxide in front-line therapy of acute promyelocytic leukemia (C9710): prognostic significance of FLT3 mutations and complex karyotype.

Authors:  Xavier Poiré; Barry K Moser; Robert E Gallagher; Kristina Laumann; Clara D Bloomfield; Bayard L Powell; Gregory Koval; Kabir Gulati; Nicholas Holowka; Richard A Larson; Martin S Tallman; Frederick R Appelbaum; Dorie Sher; Cheryl Willman; Elisabeth Paietta; Wendy Stock
Journal:  Leuk Lymphoma       Date:  2014-02-04

10.  Secondary near-tetraploidy with double der(15)t(15;17) in acute promyelocytic leukemia in relapse.

Authors:  Yuriko Morita; Asami Takahashi; Koh Yamamoto; Tohru Miki; Naomi Murakami; Osamu Miura
Journal:  Cancer Genet Cytogenet       Date:  2004-03
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  2 in total

1.  Identification of chromosomal abnormalities and genomic features in near-triploidy/tetraploidy-acute leukemia by fluorescence in situ hybridization.

Authors:  Ruqing Yang; Minghua Jiang; Junzhao Zhao; Hui Chen; Jian Gong; Yaying You; Laiyue Song; Zhen Li; Qian Li
Journal:  Cancer Manag Res       Date:  2019-02-15       Impact factor: 3.989

2.  Early mortality in acute promyelocytic leukemia: Potential predictors.

Authors:  Can Chen; Xilian Huang; Kaile Wang; Kuang Chen; Danquan Gao; Shenxian Qian
Journal:  Oncol Lett       Date:  2018-01-24       Impact factor: 2.967
  2 in total

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