Literature DB >> 25197393

Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature.

Feng Xu1, Guo-Sheng Feng1, Zhen-Jun Wang1, Kun-Ning Zhang2.   

Abstract

Either colonic large cell neuroendocrine carcinoma (LCNEC) or gastric squamous-cell carcinoma (SCC) is extremely rare, with a very poor prognosis due to the high rate of distant metastases. Here, we report the first case of synchronous double malignancies in form of colonic LCNEC and gastric SCC. A 66-year male underwent a right hemicolectomy for a mass obstructing the ascending colon and an emergent gastroscopic hemostasis for another hemorrhagic stomach mass. Histopathological examination confirmed colonic LCNEC displaying the characteristic of large, vesicular nuclei with variable amounts of cytoplasm and gastroscopic biopsy revealed poorly-differentiated gastric SCC. Immunohistochemical staining of LCNEC demonstrated positive activities for chromogranin A, synaptophysin, CD56, NSE, ki-67 (>95%), but negative for CD99, CK20 and TTF-1. The patient had suffered from an accelerated growth of multiple liver metastases after surgery, suggestive of concomitant tumor resistance (CR), and survived 2 months after discharge.

Entities:  

Keywords:  Large cell neuroendocrine carcinoma; concomitant tumor resistance; gastric squamous-cell carcinoma; pathogenesis; prognosis; secondary primary malignancy

Mesh：

Substances：

Year:  2014        PMID： 25197393      PMCID： PMC4152083     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  14 in total

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Journal:  J Natl Med Assoc       Date:  1996-05       Impact factor: 1.798

5.  [Adenocarcinoma of the stomach and neuroendocrine carcinoma of the colon in a 45-year-old male patient suffering from common variable immunodeficiency (CVID) and ulcerative colitis].

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Journal:  Z Gastroenterol       Date:  2012-12-07       Impact factor: 2.000

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Journal:  J Am Coll Surg       Date:  1995-04       Impact factor: 6.113

Review 7.  The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification.

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Journal:  Ann N Y Acad Sci       Date:  2004-04       Impact factor: 5.691

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Authors:  Rupert Prommegger; Christian Ensinger; Philipp Steiner; Tonja Sauper; Christoph Profanter; Raimund Margreiter
Journal:  Anticancer Res       Date:  2004 Mar-Apr       Impact factor: 2.480

9.  Neuroendocrine carcinomas of the colon and rectum.

Authors:  P E Bernick; D S Klimstra; J Shia; B Minsky; L Saltz; W Shi; H Thaler; J Guillem; P Paty; A M Cohen; W D Wong
Journal:  Dis Colon Rectum       Date:  2004-02       Impact factor: 4.585

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Journal:  Clin Exp Metastasis       Date:  2004       Impact factor: 5.150
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  4 in total

1.  Primary gastric squamous cell carcinoma presenting as a large submucosal mass: A case report and literature review.

Authors:  Lei Gao; Xiaolong Tang; Hui Qu; Qingsi He; Guorui Sun; Jingbo Shi; Jianhong Ye; Yahang Liang
Journal:  Medicine (Baltimore)       Date:  2020-09-04       Impact factor: 1.889

Review 2.  Synchronous of gastric adenocarcinoma and schwannoma: report of a case and review of literatures.

Authors:  Lian-He Yang; Jin-Ou Wang; Shuang Ma; Zhi Zhu; Jia-Xing Sun; Si-Lu Ding; Guang Li; Hong-Tao Xu; Liang Wang; Sun-Dong Dai; Yang Liu; Yuan Miao; Gui-Yang Jiang; Chui-Feng Fan; En-Hua Wang
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

3.  Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?

Authors:  Rafael Parra-Medina; Paula Moreno-Lucero; Julian Jimenez-Moreno; Alejandra María Parra-Morales; Alfredo Romero-Rojas
Journal:  PLoS One       Date:  2019-05-14       Impact factor: 3.240

4.  A case of colorectal large cell neuroendocrine carcinoma accompanied by disseminated peritoneal leiomyomatosis.

Authors:  Kunihiko Suga; Hiroomi Ogawa; Makoto Sohda; Chika Katayama; Naoya Ozawa; Katsuya Osone; Takuhisa Okada; Takuya Shiraishi; Ryuji Katoh; Akihiko Sano; Makoto Sakai; Takehiko Yokobori; Ken Shirabe; Hiroshi Saeki
Journal:  Surg Case Rep       Date:  2020-12-09
  4 in total

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