Yongzhong He1, Fandong Kong1, Hanpeng Du1, Mingjian Wu1. 1. Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.
Abstract
AIM: The present study was to investigate the clinical significance of Uroplakins Ia (UPKIa) in the development of colorectal cancer. METHODS: mRNA levels of UPKIa in paired colorectal cancer lesions and the adjacent noncancerous tissues were examined using real-time PCR. The expression and prognostic value of UPKIa were examined in 125 colorectal cancer patients after resection. Statistical analyses were applied to derive prognostic associations. RESULTS: UPKIa mRNA level was down-regulated in colorectal cancer lesions compared with that in the paired adjacent noncancerous tissues. Reduced expression of UPKIa was significantly associated with clinical staging (P = 0.038), and tumor size (P = 0.035) of the disease. Moreover, low expression of UPKIa was significantly associated with poorer overall (OS) and recurrent free (RFS) survival (P = 0.017 and P = 0.007, respectively) of colorectal cancer patients. Multivariate analysis suggested that reduced expression of UPK1a was an independent prognostic marker of colorectal cancer (P = 0.047). CONCLUSIONS: Low expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients. Further studies on the potential use of UPKIa as a therapeutic targetis are still needed.
AIM: The present study was to investigate the clinical significance of Uroplakins Ia (UPKIa) in the development of colorectal cancer. METHODS: mRNA levels of UPKIa in paired colorectal cancer lesions and the adjacent noncancerous tissues were examined using real-time PCR. The expression and prognostic value of UPKIa were examined in 125 colorectal cancerpatients after resection. Statistical analyses were applied to derive prognostic associations. RESULTS: UPKIa mRNA level was down-regulated in colorectal cancer lesions compared with that in the paired adjacent noncancerous tissues. Reduced expression of UPKIa was significantly associated with clinical staging (P = 0.038), and tumor size (P = 0.035) of the disease. Moreover, low expression of UPKIa was significantly associated with poorer overall (OS) and recurrent free (RFS) survival (P = 0.017 and P = 0.007, respectively) of colorectal cancerpatients. Multivariate analysis suggested that reduced expression of UPK1a was an independent prognostic marker of colorectal cancer (P = 0.047). CONCLUSIONS: Low expression of UPKIa was a promising predictor for poor outcome of colorectal cancerpatients. Further studies on the potential use of UPKIa as a therapeutic targetis are still needed.
Authors: Kar Lok Kong; Dora L Kwong; Li Fu; Tim Hon Man Chan; Leilei Chen; Haibo Liu; Yan Li; Ying-Hui Zhu; Jiong Bi; Yan-Ru Qin; Simon Ying Kit Law; Xin-Yuan Guan Journal: Cancer Res Date: 2010-10-26 Impact factor: 12.701