Literature DB >> 25197204

Photoactive Spatial Proximity Probes for Binding Pairs with Epigenetic Marks.

Roman N Ezhov1, Greg A Metzel1, Olga A Mukhina1, Catherine A Musselman2, Tatiana G Kutateladze2, Tiffany P Gustafson1, Andrei G Kutateladze1.   

Abstract

A new strategy for encoding polypeptide libraries with photolabile tags is developed. The photoassisted assay, based on conditional release of encoding tags only from bound pairs, can differentiate between peptides which have minor differences in a form of post-translational modifications with epigenetic marks. The encoding strategy is fully compatible with automated peptide synthesis. The encoding pendants are compact and do not perturb potential binding interactions.

Entities:  

Keywords:  conditional photorelease of tags; encoded combinatorial library; epigenetic marks; spatial proximity test

Year:  2014        PMID： 25197204      PMCID： PMC4151188          DOI： 10.1016/j.jphotochem.2014.06.014

Source DB:  PubMed          Journal:  J Photochem Photobiol A Chem        ISSN： 1010-6030            Impact factor:   4.291


  26 in total

1.  Photoinduced C-C bond cleavage in dithiane-carbonyl adducts: a laser flash photolysis study.

Authors:  P Vath; D E Falvey; L A Barnhurst; A G Kutateladze
Journal:  J Org Chem       Date:  2001-04-20       Impact factor: 4.354

Review 2.  Perspective Articles on the utility and application of solution-phase combinatorial chemistry.

Authors:  C M Baldino
Journal:  J Comb Chem       Date:  2000 Mar-Apr

3.  Discovery and characterization of a discretely folded homotrimeric betabetaalpha peptide.

Authors:  A R Mezo; J J Ottesen; B Imperiali
Journal:  J Am Chem Soc       Date:  2001-02-07       Impact factor: 15.419

Review 4.  Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research.

Authors:  Kit S Lam; Ruiwu Liu; Suzanne Miyamoto; Alan L Lehman; Joseph M Tuscano
Journal:  Acc Chem Res       Date:  2003-06       Impact factor: 22.384

5.  Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.

Authors:  Pedro V Peña; Foteini Davrazou; Xiaobing Shi; Kay L Walter; Vladislav V Verkhusha; Or Gozani; Rui Zhao; Tatiana G Kutateladze
Journal:  Nature       Date:  2006-05-21       Impact factor: 49.962

6.  Complex synthetic chemical libraries indexed with molecular tags.

Authors:  M H Ohlmeyer; R N Swanson; L W Dillard; J C Reader; G Asouline; R Kobayashi; M Wigler; W C Still
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

Review 7.  Studying noncovalent protein complexes by electrospray ionization mass spectrometry.

Authors:  J A Loo
Journal:  Mass Spectrom Rev       Date:  1997 Jan-Feb       Impact factor: 10.946

8.  Development of a fluorogenic probe with a transesterification switch for detection of histone deacetylase activity.

Authors:  Reisuke Baba; Yuichiro Hori; Shin Mizukami; Kazuya Kikuchi
Journal:  J Am Chem Soc       Date:  2012-08-23       Impact factor: 15.419

9.  2,6,7-trithiabicyclo[2.2.2]octanes as promising photolabile tags for combinatorial encoding.

Authors:  Roman A Valiulin; Andrei G Kutateladze
Journal:  J Org Chem       Date:  2007-12-11       Impact factor: 4.354

10.  Anomalous C-C bond cleavage in sulfur-centered cation radicals containing a vicinal hydroxy group.

Authors:  Zaiguo Li; Andrei G Kutateladze
Journal:  J Org Chem       Date:  2003-10-17       Impact factor: 4.354
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.